지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 484 - 493 (10page)
이용수
초록· 키워드
오류제보하기
Background: Thromboelastography (TEG) provides comprehensive information on the whole blood clot formation phases, whereas thrombin generation assay (TGA) reveals the endogenous thrombin levels in plasma. We investigated the potential significance of TEG and TGA parameters for prediction of clinical bleeding in hematologic patients on the basis of the patient’s platelet levels.
Methods: TEG and TGA were performed in 126 patients with thrombocytopenia or hematologic malignancies. The bleeding tendencies were stratified on the basis of the World Health Organization bleeding grade.
Results: Maximum amplitude (MA) and clot formation in TEG and endogenous thrombin potential (ETP) in TGA showed significant associations with high bleeding grades (P=0.001 and P=0.011, respectively). In patients with platelet counts ≤10×109/L, low MA values were strongly associated with a high bleeding risk. For bleeding prediction, the area under the curve (AUC) of MA (0.857) and ETP (0.809) in patients with severe thrombocytopenia tended to be higher than that of platelets (0.740) in all patients. Patients with platelet counts ≤10×109/L displayed the highest AUC of the combined MA and ETP (0.929).
Conclusions: Both TEG and TGA were considered to be good predictors of clinical bleeding in patients with severe thrombocytopenia. Combination of the ETP and MA values resulted in a more sensitive bleeding risk prediction in those with severe thrombocytopenia.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Al Dieri R / 2002 / The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding / Thromb Haemost 88 : 576 ~ 582
Dargaud Y / 2005 / Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B / Thromb Haemost 93 : 475 ~ 480
DeLoughery TG / 2010 / Management of acquired bleeding problems in cancer patients / Hematol Oncol Clin North Am 24 : 603 ~ 624
Estcourt LJ / 2014 / Prospective observational cohort study of the association between thromboelastometry, coagulation and platelet parameters and bleeding in patients with h
Gerotziafas GT / 2004 / The role of platelets and recombinant factor VIIa on thrombin generation, platelet activation and clot formation / Thromb Haemost 91 : 977 ~ 985
Dargaud Y / 2005 / Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B / Thromb Haemost 93 : 475 ~ 480
DeLoughery TG / 2010 / Management of acquired bleeding problems in cancer patients / Hematol Oncol Clin North Am 24 : 603 ~ 624
Estcourt LJ / 2014 / Prospective observational cohort study of the association between thromboelastometry, coagulation and platelet parameters and bleeding in patients with h
Gerotziafas GT / 2004 / The role of platelets and recombinant factor VIIa on thrombin generation, platelet activation and clot formation / Thromb Haemost 91 : 977 ~ 985
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