지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 16 - 22 (7page)
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초록· 키워드
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Purpose: This study investigated predictive factors for severe neonatal thrombocytopenia, which greatly increases the need for intensive care and is associated with a high mortality rate in premature infants. Factors adopted for prompt identification of at-risk newborns include blood test results and birth history. This study analyzed the relationship between the presence of severe neonatal thrombocytopenia and the mortality rate. The causes of thrombocytopenia in premature infants were also examined. Methods: This retrospective study evaluated 625 premature infants admitted to the neonatal intensive care unit (NICU) at Chung-Ang University Medical Center. The neonates were classified into 3 groups according to the severity of thrombocytopenia: mild (100×109/L≤platelet<150×109/L), moderate (50×109/L≤platelet<100×109/L), or severe (platelet<50×109/L). Analysis of blood samples obtained at the onset of thrombocytopenia included platelet count, white blood cell (WBC) count, hemoglobin level, hematocrit level, absolute neutrophil count, and high-sensitivity C-reactive protein level. Results: Of the 625 premature infants admitted to our NICU, 214 were detected with thrombocytopenia. The mortality rate in thrombocytopenic neonates was 18.2% (39/ 214), whereas a mortality rate of only 1.0% was observed in non-thrombocytopenic neonates. The major causes of thrombocytopenia were perinatal insufficiency and sepsis in premature infants. Severe thrombocytopenia was noted more frequently in premature infants with higher WBC counts and in those with a younger gestational age. Conclusion: Platelet count, WBC count, and gestational age are reliable predictors for severe neonatal thrombocytopenia. The major causes of thrombocytopenia were perinatal insufficiency and sepsis in premature infants.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Pahal GS / 2000 / Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation / Am J Obstet Gynecol 183:1029~1034
Burrows RF / 1988 / Incidentally detected thrombocytopenia in healthy mothers and their infants / N Engl J Med 319:142~145
Sainio S / 2000 / Thrombocytopenia in term infants: a populationbased study / Obstet Gynecol 95:441~446
de Moerloose P / 1998 / Neonatal thrombocytopenia: incidence and characterization of maternal antiplatelet antibodies by MAIPA assay / Br J Haematol 100:735~740
Burrows RF / 1993 / Fetal thrombocytopenia and its relation to maternal thrombocytopenia / N Engl J Med 329:1463~1466
Burrows RF / 1988 / Incidentally detected thrombocytopenia in healthy mothers and their infants / N Engl J Med 319:142~145
Sainio S / 2000 / Thrombocytopenia in term infants: a populationbased study / Obstet Gynecol 95:441~446
de Moerloose P / 1998 / Neonatal thrombocytopenia: incidence and characterization of maternal antiplatelet antibodies by MAIPA assay / Br J Haematol 100:735~740
Burrows RF / 1993 / Fetal thrombocytopenia and its relation to maternal thrombocytopenia / N Engl J Med 329:1463~1466
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