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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 156 - 161 (6page)
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Purpose: Thrombocytopenia is the most common hematologic abnormality diagnosed in the neonatal intensive care unit (NICU). We investigated the causes and neonatal outcomes of early-onset thrombocytopenia in preterm neonates and compared clinical outcomes between neonates in an early-onset thrombocytopenia group who have received and those who have not received platelet transfusion in order to assess the clinical significance of early-onset thrombocytopenia in preterm infants.
Methods: We retrospectively reviewed the medical records of preterm neonates born earlier than 34 weeks’ gestation who were admitted to the NICU between January 2005 and September 2014. 412 preterm neonates born earlier than 34 weeks’ gestation were enrolled. The early-onset thrombocytopenia group (n=90) had a platelet count ≤150,000/mL within the first 72 hours of life. We investigated maternal and neonatal characteristics, and neonatal outcomes in the group and compared these with those of a control group (n=322).
Results: The neonates with early-onset thrombocytopenia tended to have lower gestational age, birth weight and Apgar scores than controls. Maternal hypertension and lower Apgar score at birth were predictive factors of early-onset thrombocytopenia.
No differences in clinical outcomes were observed between the two groups.
Clinical outcomes did not significantly different between the groups regardless of whether the neonates received platelet transfusion or not.
Conclusion: Early-onset thrombocytopenia had no effect on the neonatal outcomes of the preterm infants. Platelet transfusion did not affect the clinical outcomes of the neonates in the early-onset thrombocytopenia group. Thus, we suggest a lager controlled study on early-onset thrombocytopenia in newborns in order to establish more-efficient treatment guidelines.
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참고문헌 (24)
참고문헌 신청
Baer VL / 2009 / Severe thrombocytopenia in the NICU / Pediatrics 124 : e1095 ~ 1100
Beiner ME / 2003 / Risk factors for neonatal thrombocytopenia in preterm infants / Am J Perinatol 20 : 49 ~ 54
Bell MJ / 1978 / Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging / Ann Surg 187 : 1 ~ 7
Boutaybi N / 2014 / Early-onset thrombocytopenia in nearterm and term infants with perinatal asphyxia / Vox Sang 106 : 361 ~ 367
Charkravoty S / 2012 / How I manage neonatal thrombocytopenia / Br J Haematol 156 : 155 ~ 162
Beiner ME / 2003 / Risk factors for neonatal thrombocytopenia in preterm infants / Am J Perinatol 20 : 49 ~ 54
Bell MJ / 1978 / Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging / Ann Surg 187 : 1 ~ 7
Boutaybi N / 2014 / Early-onset thrombocytopenia in nearterm and term infants with perinatal asphyxia / Vox Sang 106 : 361 ~ 367
Charkravoty S / 2012 / How I manage neonatal thrombocytopenia / Br J Haematol 156 : 155 ~ 162
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