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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 7 - 13 (7page)
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초록· 키워드
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ObjectiveThis study investigated the effect of an antenatal corticosteroid (ACS) in preterm small-for-gestational-age (SGA) neonate. MethodsThis study was a retrospective cohort study. We compared women who received ACS with unexposed controls and evaluated neonatal complications among those having a singleton SGA neonate born between 29 and 34 complete gestational weeks. The neonates born after 32 weeks of gestation were divided into subgroups. Multivariable logistic regression analysis was performed. ResultsA total 82 of the preterm infants met inclusion criteria; 57 (69.5%) were born after 32 weeks of gestation. There were no significantdifferences in terms of mechanical ventilation, seizure, intracranial hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, feeding difficulty, and neonatal mortality between infants whose mothers received ACS ant those whose mothers did not (all P>0.05). However, newborns whose mothers received ACS exhibited a significantly increased risk of developing respiratory distress syndrome (RDS) (adjusted odds ratio [aOR], 3.271; 95% confidence interval[CI], 1.038-10.305; P=0.043). In case of neonates born beyond 32 weeks of gestation, the risk of neonatal hypoglycemiawas significantly higher in women receiving ACS after controlling for confounding factors (aOR, 5.832; 95% CI, 1.096-31.031; P=0.039). ConclusionACS did not improve neonatal morbidities, in SGA neonates delivered between 29 and 34 gestational weeks. Rather, ACS could increase the risk of RDS. In cases of SGA neonate delivered between 32 and 34 complete gestational weeks, the risk of hypoglycemia was significantly increased. The use of ACS in women with preterm SGA infants needs to be evaluated further, especially after 32 weeks’ gestation.
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참고문헌 (21)
참고문헌 신청
1995 / Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes / JAMA 273:413~418
Gyamfi-Bannerman C / 2016 / Antenatal betamethasone for women at risk for late preterm delivery / N Engl J Med 374:1311~1320
American College of Obstetricians / 2016 / Committee opinion no.677: antenatal corticosteroid therapy for fetal maturation / Obstet Gynecol 128:e187~e194
Liggins GC / 1972 / A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants / Pediatrics 50:515~525
Amiya RM / 2016 / Antenatal corticosteroids for reducing adverse maternal and child outcomes in special populations of women at risk of imminent preterm birth: a systematic review and meta-analysis / PLoS One 11:e0147604
Gyamfi-Bannerman C / 2016 / Antenatal betamethasone for women at risk for late preterm delivery / N Engl J Med 374:1311~1320
American College of Obstetricians / 2016 / Committee opinion no.677: antenatal corticosteroid therapy for fetal maturation / Obstet Gynecol 128:e187~e194
Liggins GC / 1972 / A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants / Pediatrics 50:515~525
Amiya RM / 2016 / Antenatal corticosteroids for reducing adverse maternal and child outcomes in special populations of women at risk of imminent preterm birth: a systematic review and meta-analysis / PLoS One 11:e0147604
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