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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 300 - 305 (6page)
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초록· 키워드
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Background: Acute heart failure negatively affects short-term outcomes of patients with acute coronary syndrome (ACS). Therefore, reliable and non-invasive assessment of pulmonary congestion is needed to select patients requiring more intensive monitoring and therapy. Since plasma levels of natriuretic peptides are influenced by myocardial ischemia, they might not reliably reflect congestion in the context of ACS. The novel endothelial biomarker, soluble CD146 (sCD146), presents discriminative power for detecting the cardiac origin of acute dyspnea similar to that of natriuretic peptides and is associated with systemic congestion. We evaluated the performance of sCD146 for the assessment of pulmonary congestion in the early phase of ACS.
Methods: One thousand twenty-one consecutive patients with ACS were prospectively enrolled. Plasma levels of sCD146, brain natriuretic peptide (BNP), and high-sensitive troponin T were measured within 24 hr after the onset of chest pain. Pulmonary congestion on chest radiography was determined and classified in three groups according to the degree of congestion.
Results: Nine hundred twenty-seven patients with ACS were analyzed. Ninety-two (10%) patients showed signs of pulmonary edema on chest radiography. Plasma levels of sCD146 reflected the radiological severity of pulmonary congestion. Higher plasma levels of sCD146 were associated with the worse degree of pulmonary congestion. In contrast to BNP, sCD146 levels were not affected by the level of troponin T.
Conclusions: The novel endothelial biomarker, sCD146, correlates with radiological severity of pulmonary congestion in the early phase of ACS and, in contrast to BNP, is not affected by the amount of myocardial cell necrosis.
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Fonarow GC / 2008 / Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF / Arch Intern Med 168:847~854
Bahit MC / 2013 / Heart failure complicating non-ST-segment elevation acute coronary syndrome: timing, predictors, and clinical outcomes / JACC Heart Fail 1:223~229
Heeschen C / 2004 / N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes / Circulation 110:3206~3212
Sabatine MS / 2004 / Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia / J Am Coll Cardiol 44:1988~1995
Gayat E / 2015 / Soluble CD146, a new endothelial biomarker of acutely decompensated heart failure / Int J Cardiol 199:241~247
Bahit MC / 2013 / Heart failure complicating non-ST-segment elevation acute coronary syndrome: timing, predictors, and clinical outcomes / JACC Heart Fail 1:223~229
Heeschen C / 2004 / N-terminal pro-B-type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes / Circulation 110:3206~3212
Sabatine MS / 2004 / Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia / J Am Coll Cardiol 44:1988~1995
Gayat E / 2015 / Soluble CD146, a new endothelial biomarker of acutely decompensated heart failure / Int J Cardiol 199:241~247
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