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- 자료유형
- 학술저널
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- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제18권 제1호
- 발행연도
- 2019.1
- 수록면
- 19 - 29 (11page)
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Background and Purpose: Subjective cognitive decline (SCD) may be the first symptomaticstage of Alzheimer's disease (AD). Hence, a screening tool to characterize the patients'complaints and assess the risk of AD is required. We investigated the SCD neuroimagingbiomarker distributions and the relevance between the self-report questionnaire andAlzheimer's pathologic changes. Methods: Individuals aged 50 and above with consistent cognitive complaints withoutany objective cognitive impairments were eligible for the study. The newly developedquestionnaire consisted of 2 parts; 10 questions translated from the ‘SCD-plus criteria’and a Korean version of the cognitive failure questionnaire by Broadbent. All the subjectsunderwent physical examinations such as blood work, detailed neuropsychological tests,the self-report questionnaire, brain magnetic resonance imagings, and florbetaben positronemission tomography (PET) scans. Amyloid PET findings were interpreted using both visualrating and quantitative analysis. Group comparisons and association analysis were performedusing SPSS (version 18.0). Results: A total of 31 participants with SCD completed the study and 25.8% showedpositive amyloid depositions. The degree of periventricular white matter hyperintensities(WMH) and hippocampal atrophy were more severe in amyloid-positive SCDs compared tothe amyloid-negative group. In the self-reported questionnaire, the ‘informant's report adecline’ and ‘symptom's onset after 65 years of age’ were associated with more Alzheimer'spathologic changes. Conclusions: Amyloid-positive SCDs differed from amyloid-negative SCDs on WMH,hippocampal atrophy, and a few self-reported clinical features, which gave clues on theprediction of AD pathology.
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참고문헌 (28)
참고문헌 신청
Reisberg B / 2008 / The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease / Alzheimers Dement 4:S98~S108
Jessen F / 2014 / A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease / Alzheimers Dement 10:844~852
홍윤정 / 2017 / Subjective Cognitive Decline and Alzheimer’s Disease Spectrum Disorder / Dementia and Neurocognitive Disorders(대한치매학회지) 16(2):40~47
Sperling RA / 2011 / Toward defining the preclinical stages of Alzheimer's disease: recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:280~292
Buckley RF / 2016 / A conceptualization of the utility of subjective cognitive decline in clinical trials of preclinical Alzheimer's disease / J Mol Neurosci 60:354~361
Jessen F / 2014 / A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease / Alzheimers Dement 10:844~852
홍윤정 / 2017 / Subjective Cognitive Decline and Alzheimer’s Disease Spectrum Disorder / Dementia and Neurocognitive Disorders(대한치매학회지) 16(2):40~47
Sperling RA / 2011 / Toward defining the preclinical stages of Alzheimer's disease: recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease / Alzheimers Dement 7:280~292
Buckley RF / 2016 / A conceptualization of the utility of subjective cognitive decline in clinical trials of preclinical Alzheimer's disease / J Mol Neurosci 60:354~361
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