Presepsin (soluble CD14 subtype) as a risk factor for the development of infectious and inflammatory complications in operated colorectal cancer patients

Shakeyev Kayrat; Turgunov Yermek; Ogizbayeva Alina; Avdiyenko Olga; Mugazov Miras; Grigolashvili Sofiko; Azizov Ilya

doi:10.3393/ac.2022.00115.0016

추천

검색

자료유형: 학술저널

저자정보: Shakeyev Kayrat (NJSC “Karaganda Medical University”) Turgunov Yermek (NJSC “Karaganda Medical University”) Ogizbayeva Alina (NJSC “Karaganda Medical University”) Avdiyenko Olga (NJSC “Karaganda Medical University”) Mugazov Miras (NJSC “Karaganda Medical University”) Grigolashvili Sofiko (NJSC “Karaganda Medical University”) Azizov Ilya (Laboratory of National Research Institute of Antimicrobial Chemotherapy Smolensk State Medical Univ)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.38 No.6

발행연도: 2022.12

수록면: 442 - 448 (7page)

DOI: 10.3393/ac.2022.00115.0016

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: In this pilot study the dynamic of presepsin (soluble CD14 subtype, sCD14-ST) in blood serum was assessed as a possible risk factor for the development of systemic inflammatory response syndrome (SIRS) and infectious and inflammatory complications in operated colorectal cancer patients. Methods: To determine sCD14-ST by enzyme-linked immunosorbent assay method venous blood was taken 1 hour before surgery and 72 hours after it (3rd day). The presence of SIRS and organ dysfunctions (ODs) according to the Sequential Organ Failure Assessment scale were assessed. Results: Thiry-six patients with colorectal cancer were enrolled in the study. sCD14-ST level before surgery was 269.8±103.1 pg/mL (interquartile range [IQR], 196.7–327.1 pg/mL). Despite the presepsin level on the 3rd day being higher (291.1±136.5 pg/mL; IQR, 181.2–395.5 pg/mL), there was no statistical significance in its dynamics (P=0.437). sCD14-ST value both before surgery and on the 3rd day after it was significantly higher in patients with bowel obstruction (P=0.038 and P=0.007). sCD14-ST level before surgery above 330 pg/mL showed an increase in the probability of complications, SIRS, and OD (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.1–28.2; OR, 7.0; 95% CI, 1.3–36.7; and OR, 13.0; 95% CI, 1.1–147.8; respectively). Patients with OD had higher levels on the 3rd day after surgery (P=0.049). Conclusion: sCD14-ST level in operated colorectal cancer patients was much higher if they were admitted with complication like bowel obstruction. Higher preoperative levels of sCD14-ST increase the probability of postoperative complications, SIRS, and OD. Therefore, further studies with large sample size are needed.

#sCD14-ST #Colorectal neoplasms #Intestinal obstruction #Systemic inflammatory response syndrome #Complications

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!