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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제39권 제2호
- 발행연도
- 2009.1
- 수록면
- 119 - 128 (10page)
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Purpose: The aim of this study was to evaluate the stemness of cells from canine dental tissues and bone marrow.
Methods: Canine periodontal ligament stem cells (PDLSC), alveolar bone stem cells (ABSC) and bone marrow stem
cells(BMSC) were isolated and cultured. Cell differentiations (osteogenic, adipogenic and chondrogenic) and surface antigens
(CD146, STRO-1, CD44, CD90, CD45, CD34) were evaluated in vitro. The cells were transplanted into the subcutaneous
space of nude mice to assess capacity for ectopic bone formation at 8 weeks after implantation.
Results: PDLSC, ABSC and BMSC differentiated into osteoblasts, adipocytes and chondrocytes under defined condition. The
cells expressed the mesenchymal stem cell markers differently. When transplanted into athymic nude mice, these three kinds
of cells with hydroxyapatite /β- tricalcium phosphate (HA/TCP) carrier showed ectopic bone formation.
Conclusions: This study demonstrated that canine dental stem cells have stemness like bone marrow stem cells.
Transplantation of these cells might be used as a therapeutic approach for dental stem cell-mediated periodontal tissue
regeneration. (J Korean Acad Periodontol 2009;39:119-128)
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bianco P / 2001 / Stem cells in tissue engineering / Nature 414 : 118 ~ 121
Bruder SP / 1997 / Monoclonal antibodies reactive with human osteogenic cell surface antigens / Bone 21 : 225 ~ 235
Bruder SP / 1998 / The effect of implants loaded with autogenous mesenchymal stem cells on the healing of canine segmental bone defects / J Bone and Joint Surg 80 (A) : 986 ~
Cai J / 2004 / In search of “stemness” / Exp Hematol 32 : 585 ~ 598
Caplan AI / 2005 / Mesenchymal stem cells: cell-based reconstructive therapy in orthopedics / Tissue Engineering 11 : 1198 ~ 1211
Bruder SP / 1997 / Monoclonal antibodies reactive with human osteogenic cell surface antigens / Bone 21 : 225 ~ 235
Bruder SP / 1998 / The effect of implants loaded with autogenous mesenchymal stem cells on the healing of canine segmental bone defects / J Bone and Joint Surg 80 (A) : 986 ~
Cai J / 2004 / In search of “stemness” / Exp Hematol 32 : 585 ~ 598
Caplan AI / 2005 / Mesenchymal stem cells: cell-based reconstructive therapy in orthopedics / Tissue Engineering 11 : 1198 ~ 1211
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