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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 210 - 216 (7page)
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초록· 키워드
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Recently, there has been a considerable increase in the prevalence of CTX-M type exten-ded-spectrum -lactamase (ESBL)-producing E. coli isolates worldwide, including Korea. To investigate the ESBL genes in the E. coli strains isolated from a university hospital in the Chungcheong area, a study was conducted using PCR amplification and nucleotide sequence analysis of the amplified products to detect the plasmid mediated quinolone resistance (PMQR) genes in ESBL producing E. coli isolates. The number of CTX-M-14 producing isolates was 25 (16.0%) isolates, and of them, 9 (5.8%) isolates also produced CTX-M-15. All CTX-M type ESBL producing E. coli isolates showed resistance to cefotaxime. Twelve (48%) CTX-M type ESBL producing E. coli isolates contained the PMQR genes, 8 contained qnrS1, and 8 contained aac(6’)-Ib-cr. Four isolates harbored both qnrS1 and aac(6’)-Ib-cr genes. In our study, we confirmed that the plasmid mediated antimicrobial resistant determinants—the ESBL and PMQR genes—were distributed in the E. coli isolates. To prevent further spreading of the resistant genes among the E. coli isolates, consistent effort is required to investigate and monitor the resistant genes.
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참고문헌 (19)
참고문헌 신청
Qadri F / 2005 / Enterotoxigenic Escherichia coli in developing countries : epidemiology, microbiology, clinical features, treatment, and prevention / Clin Microbiol Rev 18:465~483
Canton R / 2012 / CTX-M enzymes : origin and diffusion / Front Microbiol 3:110
Poirel L / 2002 / Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases / Antimicrob Agents Chemother 46:4038~4040
Song W / 2009 / CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea / J Med Microbiol 58:261~266
Seo MR / 2010 / Characteristics of plasmid mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant isolates of Klebsiella pneumoniae and Escherichia coli in Korea / Chemotherapy 56:46~53
Canton R / 2012 / CTX-M enzymes : origin and diffusion / Front Microbiol 3:110
Poirel L / 2002 / Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases / Antimicrob Agents Chemother 46:4038~4040
Song W / 2009 / CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea / J Med Microbiol 58:261~266
Seo MR / 2010 / Characteristics of plasmid mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant isolates of Klebsiella pneumoniae and Escherichia coli in Korea / Chemotherapy 56:46~53
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