지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 197 - 204 (8page)
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초록· 키워드
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Multiple myeloma (MM) is the leading cause of death among hematologic neoplasms. Recently, microRNA has been reported to be useful in the diagnosis of multiple myeloma. This study examined whether miR-221 could be used as a diagnostic marker for multiple myeloma. The study was performed on 20 patients with multiple myeloma without any other hematological diseases. MicroRNA extraction was performed using formalin-fixed paraffin-embedded (FFPE) tissues obtained from the bone marrow of patients with multiple myeloma. miR-15a, miR-16, miR-21, miR-181a, and miR-221 were selected as the microRNA target genes for multiple myeloma. The significance of microRNA was based on a fold change of ＜1.5. To quantify the fold changes, data normalized to the human gene, SNORD43, were used as the values of the patient group. Fold change values greater than 1.5 were defined as “overexpression”, whereas values less than -1.5 were defined as “underexpression”. Of note, 65.0% (13/20) of samples showed significant “overexpression” in the levels of miR-221 expression and plasma cells with a group of more and less than 30% in MM patients did not show any significance of plasma cell (P＜0.05). The results of other studies showing a correlation between the expression of miR-221 and MM in Caucasians were confirmed. These results suggest that miR-221 may be a useful indicator for diagnosing patients with MM. In conclusion, miR-221 is useful in the diagnosis and determining the prognosis of multiple myeloma in Koreans.
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참고문헌 (32)
참고문헌 신청
Alexander DD / 2007 / Multiple myeloma: a review of the epidemiologic literature / Int J Cancer 120(Suppl 12):40~61
Ribatti D / 2006 / Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma / Oncogene 25:4257~4266
Greipp PR / 2005 / International staging system for multiple myeloma / J Clin Oncol 23:3412~3420
Chng WJ1 / 2005 / Targeted therapy in multiple myeloma / Cancer Control 12:91~104
Raab MS / 2009 / Multiple myeloma / Lancet 374:324~339
Ribatti D / 2006 / Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma / Oncogene 25:4257~4266
Greipp PR / 2005 / International staging system for multiple myeloma / J Clin Oncol 23:3412~3420
Chng WJ1 / 2005 / Targeted therapy in multiple myeloma / Cancer Control 12:91~104
Raab MS / 2009 / Multiple myeloma / Lancet 374:324~339
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