지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 81 - 88 (8page)
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초록· 키워드
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Purpose: The American Society for Apheresis provides clinical guidelines for therapeutic apheresis in adults, but there are no guidelines for children. This study aimed to analyze the effect of therapeutic plasma exchange (TPE) in pediatric patients with various kidney diseases in Korea.
Methods: We retrospectively reviewed the data of 16 children (up to 18 years of age) who were admitted to Severance Children’s Hospital with refractory kidney disease. All patients received TPE between 1994 and 2016. Clinical and laboratory characteristics such as age, weight, sex, change in blood urea nitrogen (BUN), and creatinine level before and after TPE, and complications after TPE were analyzed.
Results: The mean age and weight of the 16 patients at the time of TPE was 11.3± 4.0 years and 34.6±17.5 kg, respectively. The BUN level was 35.4 mg/dL before TPE and significantly decreased to 21.5 mg/dL (P =0.025) at 1 week and 20.5 mg/dL (P = 0.01) at 1 month after TPE. The creatinine level significantly decreased from 1.20 mg/dL before TPE to 0.90 mg/dL (P=0.02) at 1 week after TPE. Four complications (hypovolemia, anemia, hypocalcemia, and thrombocytopenia) were reported, but were not fatal.
Conclusion: Our findings suggest that TPE is an effective therapeutic modality in children with refractory kidney disease and can be indicated for the treatment of various kidney diseases.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abel JJ / 1990 / Plasma removal with return of corpuscles (plasmaphaeresis). The Journal of Pharmacology and experimental therapeutics Vol. V. No. 6, July, 1914 / Transfus Sc
Basic-Jukic N / 2005 / Complications of therapeutic plasma exchange:experience with 4857 treatments / Ther Apher Dial 9 : 391 ~ 395
Baweja S / 2011 / Benefits and limitations of plasmapheresis in renal diseases: an evidence-based approach / J Artif Organs 14 : 9 ~ 22
Blum D / 2015 / Lupus-associated thrombotic thrombocytopenic purpura-like microangiopathy / World J Nephrol 4 : 528 ~ 531
Carter CE / 2014 / Therapeutic plasma exchange for the treatment of pediatric renal diseases in 2013 / Pediatr Nephrol 29 : 35 ~ 50
Basic-Jukic N / 2005 / Complications of therapeutic plasma exchange:experience with 4857 treatments / Ther Apher Dial 9 : 391 ~ 395
Baweja S / 2011 / Benefits and limitations of plasmapheresis in renal diseases: an evidence-based approach / J Artif Organs 14 : 9 ~ 22
Blum D / 2015 / Lupus-associated thrombotic thrombocytopenic purpura-like microangiopathy / World J Nephrol 4 : 528 ~ 531
Carter CE / 2014 / Therapeutic plasma exchange for the treatment of pediatric renal diseases in 2013 / Pediatr Nephrol 29 : 35 ~ 50
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