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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 39 - 45 (7page)
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Purpose: Dieckol, a phlorotannin compound isolated from Ecklonia cava, has been reported to have antioxidant, antiviral, anti-inflammatory, and anticancer properties. The purpose of this study was to investigate its anticancer effects on human breast cancer cell lines. Methods: In this study, the viability of two human breast cancer cell lines SK-BR-3 and MCF-7 was investigated after dieckol treatment using a WST-1 assay. Apoptosis and cell cycle distribution were assayed via Annexin V-fluorescein isothiocyanate and propidium iodide staining followed by flow cytometric analysis. Immunoblotting analysis was also performed using Bax/Bcl-2 to determine whether the dieckol-induced apoptosis was mediated by the intrinsic apoptotic pathway. Results: In a dose dependent manner, dieckol reduced the number of viable cells and increased the number of apoptotic cells. The effect of dieckol on the cell cycle distribution was analyzed using flow cytometry. Dieckol treatment significantly increased the percentage of MCF-7 and SK-BR-3 in the G2/M phase. Immunoblot analysis revealed that 24 hours of dieckol exposure increased the Bax/Bcl-2 ratio. Conclusion: Dieckol induced cytotoxicity in MCF-7 and SK-BR-3 human breast cancer cells inducing apoptosis and cell cycle arrest. Therefore, it is suggested that dieckol may be a potential therapeutic agent for breast cancer.
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참고문헌 (30)
참고문헌 신청
DeSantis C / 2014 / Breast cancer statistics, 2013 / CA Cancer J Clin 64:52~62
Lee JH / 2013 / The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression / Oncol Rep 29:917~924
Perou CM / 2000 / Molecular portraits of human breast tumours / Nature 406:747~752
Sørlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Sotiriou C / 2003 / Breast cancer classification and prognosis based on gene expression profiles from a population-based study / Proc Natl Acad Sci U S A 100:10393~10398
Lee JH / 2013 / The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression / Oncol Rep 29:917~924
Perou CM / 2000 / Molecular portraits of human breast tumours / Nature 406:747~752
Sørlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Sotiriou C / 2003 / Breast cancer classification and prognosis based on gene expression profiles from a population-based study / Proc Natl Acad Sci U S A 100:10393~10398
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