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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,095 - 1,105 (11page)
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Purpose: Appropriate animal models of atherosclerotic plaque are crucial to investigating the pathophysiology of atherosclerosis, as well as for the evaluation of the efficacy and safety of vascular devices. We aimed to develop a novel animal model that would be suitable for the study of advanced atherosclerotic lesions in vivo.
Materials and Methods: Atherosclerotic plaque was induced in 24 iliac arteries from 12 rabbits by combining a high cholesterol diet, endothelial denudation, and injection into the vessel wall with either saline (n=5), olive oil (n=6), or inflammatory proteins [n=13, high-mobility group protein B1 (HMGB1) n=8 and tumor necrosis factor (TNF)-α n=5] using a CricketTM Micro-infusion catheter. Optical coherence tomography (OCT) was performed to detect plaque characteristics after 4 weeks, and all tissues were harvested for histological evaluation.
Results: Advanced plaque was more frequently observed in the group injected with inflammatory proteins. Macrophage infiltrationwas present to a higher degree in the HMGB1 and TNF-α groups, compared to the oil or saline group (82.1±5.1% and 94.6± 2.2% compared to 49.6±14.0% and 46.5±9.6%, p-value<0.001), using RAM11 antibody staining. On OCT, lipid rich plaques were more frequently detected in the inflammatory protein group [saline group: 2/5 (40%), oil group: 3/5 (50%), HMGB1 group: 6/8 (75%), and TNF-α group: 5/5 (100%)].
Conclusion: These data indicate that this rabbit model of atherosclerotic lesion formation via direct injection of pro-inflammatory proteins into the vessel wall is useful for in vivo studies investigating atherosclerosis.
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참고문헌 (19)
참고문헌 신청
Arbab-Zadeh A / 2012 / Acute coronary events / Circulation 125:1147~1156
Otsuka F / 2014 / Clinical classification of plaque morphology in coronary disease / Nat Rev Cardiol 11:379~389
Virmani R / 2006 / Pathology of the vulnerable plaque / J Am Coll Cardiol 47(8 Suppl):C13~C18
Bentzon JF / 2014 / Mechanisms of plaque formation and rupture / Circ Res 114:1852~1866
Granada JF / 2007 / In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions / Arterioscler Thromb Vasc Biol 27:387~393
Otsuka F / 2014 / Clinical classification of plaque morphology in coronary disease / Nat Rev Cardiol 11:379~389
Virmani R / 2006 / Pathology of the vulnerable plaque / J Am Coll Cardiol 47(8 Suppl):C13~C18
Bentzon JF / 2014 / Mechanisms of plaque formation and rupture / Circ Res 114:1852~1866
Granada JF / 2007 / In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions / Arterioscler Thromb Vasc Biol 27:387~393
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