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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 349 - 361 (13page)
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Atherosclerosis is the leading cause of life-threatening morbidity and mortality, as the rupture of atherosclerotic plaques leads to critical atherothrombotic events such as myocardial infarction and ischemic stroke, which are the 2 most common causes of death worldwide. Vascular calcification is a complicated pathological process involved in atherosclerosis, and microcalcifications are presumed to increase the likelihood of plaque rupture. Despite many efforts to develop novel non-invasive diagnostic modalities, diagnostic techniques are still limited, especially before symptomatic presentation. From this point of view, vulnerable plaques are a direct target of atherosclerosis imaging. Anatomic imaging modalities have the limitation of only visualizing macroscopic structural changes, which occurs in later stages of disease, while molecular imaging modalities are able to detect microscopic processes and microcalcifications, which occur early in the disease process. Na[18F]-fluoride positron emission tomography/computed tomography could allow the early detection of plaque instability, which is deemed to be a primary goal in the prevention of cardiac or brain ischemic events, by quantifying the microcalcifications within vulnerable plaques and evaluating the atherosclerotic disease burden.
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참고문헌 (84)
참고문헌 신청
Heron M / 2013 / Deaths : leading causes for 2010 / Natl Vital Stat Rep 62:1~96
Benjamin EJ / 2019 / Heart disease and stroke statistics-2019 update : a report from the American Heart Association / Circulation 139:e56~e528
Demer LL / 2003 / Mineral exploration : search for the mechanism of vascular calcification and beyond : the 2003 Jeffrey M. Hoeg Award lecture / Arterioscler Thromb Vasc Biol 23:1739~1743
Johnson RC / 2006 / Vascular calcification : pathobiological mechanisms and clinical implications / Circ Res 99:1044~1059
Wu M / 2013 / Vascular calcification : an update on mechanisms and challenges in treatment / Calcif Tissue Int 93:365~373
Benjamin EJ / 2019 / Heart disease and stroke statistics-2019 update : a report from the American Heart Association / Circulation 139:e56~e528
Demer LL / 2003 / Mineral exploration : search for the mechanism of vascular calcification and beyond : the 2003 Jeffrey M. Hoeg Award lecture / Arterioscler Thromb Vasc Biol 23:1739~1743
Johnson RC / 2006 / Vascular calcification : pathobiological mechanisms and clinical implications / Circ Res 99:1044~1059
Wu M / 2013 / Vascular calcification : an update on mechanisms and challenges in treatment / Calcif Tissue Int 93:365~373
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