지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 41 - 50 (10page)
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Purpose: The aim of this study was to investigate the safety and the effects of elevated doses of solifenacin and trospium on cognitive function and health-related quality of life (HRQoL) in elderly women receiving treatment for urinary incontinence. Methods: The study included 312 women aged 60–83 years (mean age, 69.4 years). All participants had scored at least 24 points on the Mini-Mental State Examination (MMSE) scale, and all of them had been diagnosed with urge urinary incontinence (UUI) or mixed urinary incontinence (MUI). The women were randomly assigned to 3 groups: group A, individuals who were simultaneously administered solifenacin at a high dosage of 20 mg per day and trospium at a high dosage of 60 mg per day; group B, persons taking solifenacin and trospium at the usual dosage of 10 and 30 mg per day, respectively; and group C, persons who received a placebo. Participants’ cognitive status was assessed by the MMSE, Controlled Oral Word Association Test, Wechsler Adult Intelligence Scale-Revised, Wechsler Memory Scale III, Colour Trails Test, and California Verbal Learning Test scales. The HRQoL assessment was performed using the Medical Outcomes Study 36-Item Health Survey. Results: The cognitive function parameters did not differ at the start and end of the study across the groups (P>0.05). Additionally, the cognitive function parameters did not differ significantly within each group between the start and end of the study (P>0.05). The values of most HRQoL parameters regarding the functional state of the lower urinary tract (LUT) after the termination of treatment significantly improved in groups A and B (P<0.05). A significant correlation between cognitive status and HRQoL or LUT parameters was absent (r<0.3), while the correlations between HRQoL and LUT parameters were r=0.31–0.83, P<0.05. Conclusions: The use of elevated doses of solifenacin and trospium did not increase the risk of cognitive impairment in women with UUI and MUI. The combination of solifenacin and trospium at a double dosage may be recommended to elderly women with treatment-resistant symptoms of UUI and MUI. However, the safety of combining antimuscarinic drugs in women with an increased volume of residual urine requires further study.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Abrams P / 2010 / Fourth International Consultation on Incontinence Recommendations of the International Scientific Committee: Evaluation and treatment of urinary incontinence, pelvic organ prolapse, and fecal incontinence / Neurourol Urodyn 29:213~240
Pfisterer MH / 2006 / The effect of age on lower urinary tract function: a study in women / J Am Geriatr Soc 54:405~412
Coyne KS / 2013 / The prevalence of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) by racial/ethnic group and age: results from OAB-POLL / Neurourol Urodyn 32:230~237
Sensoy N / 2013 / Urinary incontinence in women: prevalence rates, risk factors and impact on quality of life / Pak J Med Sci 29:818~822
Coyne KS / 2004 / The impact of urinary urgency and frequency on health-related quality of life in overactive bladder: results from a national community survey / Value Health 7:455~463
Pfisterer MH / 2006 / The effect of age on lower urinary tract function: a study in women / J Am Geriatr Soc 54:405~412
Coyne KS / 2013 / The prevalence of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) by racial/ethnic group and age: results from OAB-POLL / Neurourol Urodyn 32:230~237
Sensoy N / 2013 / Urinary incontinence in women: prevalence rates, risk factors and impact on quality of life / Pak J Med Sci 29:818~822
Coyne KS / 2004 / The impact of urinary urgency and frequency on health-related quality of life in overactive bladder: results from a national community survey / Value Health 7:455~463
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