지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 212 - 219 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: We performed a meta-analysis to evaluate the efficacy and safety of mirabegron add-on therapy to solifenacin for patients with overactive bladder (OAB).
Methods: We conducted a systematic literature review to identify all randomized, double-blind, controlled trials (RCTs) of this combination (mirabegron and solifenacin) for OAB. Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched. A manual search was also performed to investigate relevant references from the retrieved studies.
Results: Four publications describing 5 RCTs that compared combination therapy with solifenacin, including a total of 3,309 patients, were analyzed. The mean number of micturitions per 24 hours (mean difference [MD], -0.45; 95% confidence interval [CI], -0.65 to -0.26; P<0.00001), number of episodes of incontinence per 24 hours (MD, -0.71; 95% CI, -0.14 to -0.02; P=0.04), volume voided per micturition, and number of urgency episodes per 24 hours demonstrated that combination therapy was more effective than solifenacin therapy alone. Safety assessments, including common treatment-emergent adverse events (odds ratio, 1.09; 95% CI, 0.95–1.27; P=0.23) and discontinuations due to adverse events (P=0.30), demonstrated that the combination therapy was well tolerated.
Conclusions: This meta-analysis suggests that mirabegron therapy as an add-on to solifenacin provides a satisfactory therapeutic effect for OAB symptoms with a low occurrence of side effects.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function : report from the Standardisation Subcommittee of the International Continence Society /
Abrams P / 2015 / Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dos
Abrams P / 2017 / Combination treatment with mirabegron and solifenacin in patients with overactive bladder: exploratory responder analyses of efficacy and evaluation of pat
Agarwal A / 2014 / What is the most bothersome lower urinary tract symptom? Individual-and population-level perspectives for both men and women / Eur Urol 65 : 1211 ~ 1217
Benner JS / 2010 / Patient-reported reasons for discontinuing overactive bladder medication / BJU Int 105 : 1276 ~ 1282
Abrams P / 2015 / Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dos
Abrams P / 2017 / Combination treatment with mirabegron and solifenacin in patients with overactive bladder: exploratory responder analyses of efficacy and evaluation of pat
Agarwal A / 2014 / What is the most bothersome lower urinary tract symptom? Individual-and population-level perspectives for both men and women / Eur Urol 65 : 1211 ~ 1217
Benner JS / 2010 / Patient-reported reasons for discontinuing overactive bladder medication / BJU Int 105 : 1276 ~ 1282
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Detrusor Overactivity May Be a Prognostic Factor for Better Response to Combination Therapy Over Monotherapy in Male Patients With Benign Prostatic Enlargement and Storage Lower Urinary Tract Symptoms
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Urodynamic and Bladder Diary Factors Predict Overactive Bladderwet in Women: A Comparison With Overactive Bladder-dry
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