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논문 기본 정보

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학술저널
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대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제20권 제3호
발행연도
2016.1
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240 - 249 (10page)

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Purpose: The prevalence of hyperactive-type lower urinary tract symptoms is 45.2%, with shares of overactive bladder (OAB) and urge incontinence (UI) symptoms of 10.7% and 8.2%, respectively. We investigated the possible impact of a wide range of social, economic, and medical factors on compliance with solifenacin treatment in the working population. Methods: Social, economic, and medical factors as well as the Overactive Bladder questionnaire – the OAB-q Short Form (OAB-q SF), bladder diaries, and uroflowmetry of 1,038 people who were administered solifenacin for a year were gathered from employer documentation. Results: Among the subjects, 32% maintained their compliance with solifenacin treatment throughout the year. Only 65% of the patients had compliance exceeding 80%, and 17% of patients had compliance of ≥50%, yet less than 80% were still taking solifenacin 12 months after the beginning of this experiment. Working people whose compliance level was, at least, 80% had reliably higher (P≤0.01) average age, annual salary, and treatment efficacy, and a greater treatment satisfaction level, as well as a lack of satisfaction with other antimuscarinic treatments and higher rate of urge UI diagnosis. The same cohort also featured a lower level (P≤0.01) of caffeine abuse and lower share of salary spent purchasing solifenacin. Conclusions: This study has shown that compliance with solifenacin treatment is associated with a number of significant medical, social, and economic factors. The medical factors included the type of urination disorder, severity of incontinence symptoms, presence of side effects, treatment efficacy and patients’ satisfaction with it, and experience using other antimuscarinic treatments. Among the social and economic factors, those with the strongest correlation to compliance were patient age, employment in medicine and education, annual income level, percentage of solifenacin purchase expenditures, and caffeine abuse. Factors with a weaker, but still significant, association were gender, employment in the transportation industry, and monthly income level.
#Urinary Bladder #Overactive #Muscarinic Antagonists #Solifenacin Succinate #Compliance

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참고문헌 (30)

참고문헌 신청
Yu YF / 2005 / Persistence and adherence of medications for chronic overactive bladder/urinary incontinence in the California medicaid program / Value Health 8:495~505 google schola Sicras-Mainar A / 2014 / Antimuscarinic persistence patterns in newly treated patients with overactive bladder: a retrospective comparative analysis / Int Urogynecol J 25:485~492 google schola Chapple CR / 2008 / The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis / Eur Urol 54:543~562 google schola Tubaro A / 2004 / Defining overactive bladder: epidemiology and burden of disease / Urology 64(6 Suppl 1):2~6 google schola Milsom I / 2012 / Effect of bothersome overactive bladder symptoms on health-related quality of life, anxiety, depression, and treatment seeking in the United States: results from EpiLUTS / Urology 80:90~96 google schola

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