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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 308 - 316 (9page)
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초록· 키워드
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Purpose: We recently reported that rosiglitazone (RGTZ), a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has a protective effect against cyclosporine (CsA)- induced renal injury. Here we report the effect of RGTZ on peroxisome proliferator-activated receptor gamma (PPARγ) expression in an experimental model of chronic cyclosporine (CsA) nephropathy. Materials and Methods: Chronic CsA nephropathy was induced in Sprague-Dawley rats by administering CsA (15mg/kg per day) for 28 days, and control rats were treated with vehicle (VH group, olive oil 1mL/kg per day) for 28 days. RGTZ (3mg/kg) was concurrently administered via gavage to the CsA and VH groups. Expression of PPARγ mRNA and protein was evaluated with RT-PCR, immunohistochemistry, and immunoblotting. Results: PPARγ mRNA expression was similar to the level of PPARγ protein constitutively expressed in the kidneys of the VH treated rats, with expression in the glomerular epithelial, distal tubular cells, and collecting tubular cells. PPARγ protein expression in CsA-treated rat kidneys was significantly less than in the VH group. However, concomitant administration of RGTZ restored PPARγ protein expression in the kidneys of the CsA- reated rats. Conclusion: Exogenous administration of RGTZ treatment upregulates PPARγ expression and that this mechanism may play a role in protecting against CsA-induced renal injury.
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참고문헌 (23)
참고문헌 신청
/ 1995 / Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland 136 : 1766 ~ 1774
/ 1998 / Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line 54 : 1955 ~ 1966
/ 1999 / Expression of peroxisomal proliferator- activated receptors and retinoid X receptors in the kidney 277 : F966 ~ F973
/ 2000 / Cyclosporine nephrotoxicity: the mechanisms of cell injury by cyclosporine A in renal proximal tubular cells 32 : 1621 ~ 1622
/ 2000 / Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems 63 : 263 ~ 269
/ 1998 / Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line 54 : 1955 ~ 1966
/ 1999 / Expression of peroxisomal proliferator- activated receptors and retinoid X receptors in the kidney 277 : F966 ~ F973
/ 2000 / Cyclosporine nephrotoxicity: the mechanisms of cell injury by cyclosporine A in renal proximal tubular cells 32 : 1621 ~ 1622
/ 2000 / Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems 63 : 263 ~ 269
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