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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 764 - 770 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Since November 2006, imipenem-resistant Acinetobacter baumannii isolates have increased in Kyung
Hee University Hospital in Seoul, Korea. The purpose of this study was to determine the genetic basis and
molecular epidemiology of outbreak isolates. Materials and Methods: Forty-nine non-repetitive isolates of the
734 IRAB strains were investigated in order to determine their characteristics. The modified Hodge and the
ethylenediaminetetraacetic acid (EDTA)-disk synergy test were performed for the screening of carbapenemase and
metallo-β-lactamase production. Multiplex polymerase chain reaction (PCR) assays were performed for the
detection of genes encoding for OXA-23-like, OXA-24-like, OXA-58-like and OXA-51-like carbapenemase.
Pulsed-field gel electrophoresis (PFGE) was performed for strain identification. Results: All isolates showed 100%
resistance to ciprofloxacin and gentamicin, 97.9% resistance to cefepime, piperacillin/tazobactam, aztreonam,
ceftazidime and piperacillin, 93.9% resistance to tobramycin and 57.1% resistance to amikacin. All of the 49
isolates (100%) showed positive results in the modified Hodge test and negative results in the EDTA-disk synergy
test. They all (100%) possessed the encoding gene for an intrinsic OXA-51-like carbapenemase and an acquired
OXA-23-like carbapenemase in the multiplex PCR assay. PFGE patterns revealed that all isolates were clonally
related from A1 to A14. Conclusion: It is concluded that all of the 49 IRAB isolates acquired resistance to
imipenem by producing OXA-23 carbapenemase and they might have originated from a common source.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Abbo A / 2005 / Multidrug-resistant Acinetobacter baumannii / Emerg Infect Dis 11 : 22 ~ 29
Bergogne-Berezin E / 1996 / Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features / Clin Microbiol Rev 9 : 148 ~ 165
Bou G / 2000 / Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenemhydrolyzing enzyme: high-level carbapenem
Brown S / 2006 / OXA (beta)-lactamases in Acinetobacter: the story so far / J Antimicrob Chemother 57 : 1 ~ 3
Donald HM / 2000 / Sequence analysis of ARI-1, a novel OXA beta-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92 / Antimicrob Agents Chemother
Bergogne-Berezin E / 1996 / Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features / Clin Microbiol Rev 9 : 148 ~ 165
Bou G / 2000 / Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenemhydrolyzing enzyme: high-level carbapenem
Brown S / 2006 / OXA (beta)-lactamases in Acinetobacter: the story so far / J Antimicrob Chemother 57 : 1 ~ 3
Donald HM / 2000 / Sequence analysis of ARI-1, a novel OXA beta-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92 / Antimicrob Agents Chemother
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