지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,018 - 1,024 (7page)
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초록· 키워드
오류제보하기
Purpose: Recent neuroimaging findings have revealed that paralimbic and prefrontal regions are involved in panic disorder (PD). However, no imaging studies have compared differences in cortical thickness between patients with PD and healthy control (HC) subjects.
Materials and Methods: Forty-seven right-handed patients with PD who met the diagnostic criteria in the Diagnostic and StatisticalManual of Mental Disorders-4th edition-text revision, and 30 HC subjects were enrolled. We used the FreeSurfer software package for estimating the cortical thickness of regions of interest, including the temporal pole, insula, and pars triangularis (mid-ventrolateral prefrontal cortex).
Results: Cortical thickness of the temporal pole (p=0.033, right), insula (p=0.017, left), and pars triangularis (p=0.008, left; p=0.025, right) in patients with PD was significantly lower, compared with HC subjects (Benjamini-Hochberg false discovery rate correction).
Exploratory analysis revealed a significant negative correlation between the cortical thickness of the right temporal pole and Beck Depression Inventory scores (r=-0.333, p=0.027) in patients with PD and positive correlations between the cortical thickness of the left pars triangularis and Panic Disorder Severity Scale (r=0.429, p=0.004), Anxiety Sensitivity Index-Revised (r=0.380, p=0.011), and Beck Anxiety Inventory (r=0.421, p=0.004) scores using Pearson’s correlation.
Conclusion: Ours study is the first to demonstrate cortical thickness reduction in the temporal pole, insula, and pars triangularis in patients with PD, compared with the HC subjects. These findings suggest that reduced cortical thickness could play an importantrole in the pathophysiology of PD.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Agustin-Pavon C / 2012 / Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion / Biol Psychiatry 72 : 266 ~ 272
Beck AT / 1988 / An inventory for measuring clinical anxiety: psychometric properties / J Consult Clin Psychol 56 : 893 ~ 897
Boshuisen
Fischl B / 2000 / Measuring the thickness of the human cerebral cortex from magnetic resonance images / Proc Natl Acad Sci U S A 97 : 11050 ~ 11055
Fontaine R / 1990 / Temporal lobe abnormalities in panic disorder: an MRI study / Biol Psychiatry 27 : 304 ~ 310
Beck AT / 1988 / An inventory for measuring clinical anxiety: psychometric properties / J Consult Clin Psychol 56 : 893 ~ 897
Boshuisen
Fischl B / 2000 / Measuring the thickness of the human cerebral cortex from magnetic resonance images / Proc Natl Acad Sci U S A 97 : 11050 ~ 11055
Fontaine R / 1990 / Temporal lobe abnormalities in panic disorder: an MRI study / Biol Psychiatry 27 : 304 ~ 310
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