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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 287 - 293 (7page)
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Purpose: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasisand lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. Materials and Methods: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005–2008 (baseline) and from 2008–2011 (follow-up). Baseline serum FGF21 levels were analyzed using enzyme-linked immunosorbent assay. Results: During the average 2.8-year follow-up period, 82 participants (36.6%) developed new-onset MetS. Serum FGF21 levels were significantly higher in patients with new-onset MetS than in those without MetS (209.56±226.80 vs. 110.09±81.10, p<0.01). In multivariate adjusted models, the odds for MetS development were greater in patients with serum FGF21 levels in the highest quartile, compared to those in the lowest quartile (3.84, 95% confidence interval: 1.59–9.28). Conclusion: Serum FGF21 level was an independent predictor for new-onset MetS in a population-based prospective study.
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참고문헌 (30)
참고문헌 신청
Zhang X / 2008 / Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans / Diabetes 57:1246~1253
Kharitonenkov A / 2005 / FGF-21 as a novel metabolic regulator / J Clin Invest 115:1627~1635
Bobbert T / 2013 / Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians / Diabetes Care 36:145~149
Cross DA / 2014 / AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer / Cancer Discov 4:1046~1061
Domouzoglou EM / 2015 / Fibroblast growth factors in cardiovascular disease: the emerging role of FGF21 / Am J Physiol Heart Circ Physiol 309:H1029~H1038
Kharitonenkov A / 2005 / FGF-21 as a novel metabolic regulator / J Clin Invest 115:1627~1635
Bobbert T / 2013 / Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians / Diabetes Care 36:145~149
Cross DA / 2014 / AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer / Cancer Discov 4:1046~1061
Domouzoglou EM / 2015 / Fibroblast growth factors in cardiovascular disease: the emerging role of FGF21 / Am J Physiol Heart Circ Physiol 309:H1029~H1038
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