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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 484 - 491 (8page)
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The third lineage of T helper subsets, Th17, has recently been identified as an IL-17-producing CD4+ Th cell, and its functions and regulatory mechanisms have been extensively characterized in immune responses. Functional studies have provided evidence that Th17 cells are important for the modulation of autoimmune responses, such as chronic asthma, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. Murine Th17 cell differentiation is enhanced by the coordinated functions of distinct cytokines including TGFβ, IL-6, IL-21, and IL-23, whereas IL-2, IL-4, IFNγ, and IL-27 inhibit its differentiation. In addition,Th17 cells are controlled by several transcription factors such as RORγ t, IRF4,BATF, FoxP3, T-bet, PPARγ, E-FABP, and SOCSs. This review focuses on the functions and regulatory mechanisms of several transcription factors in the control of Th17 cell differentiation.
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참고문헌 (24)
참고문헌 신청
Acosta-Rodriguez EV / 2007 / Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helpe
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells / Nature 441 : 235 ~ 238
Bettelli E / 2007 / Th17: the third member of the effector T cell trilogy / Curr Opin Immunol 19 : 652 ~ 657
Carrier Y / 2007 / Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice / J Immunol
Carrier Y / 2007 / Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity / J Immunol 178 : 172 ~ 178
Bettelli E / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells / Nature 441 : 235 ~ 238
Bettelli E / 2007 / Th17: the third member of the effector T cell trilogy / Curr Opin Immunol 19 : 652 ~ 657
Carrier Y / 2007 / Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice / J Immunol
Carrier Y / 2007 / Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity / J Immunol 178 : 172 ~ 178
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