지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 843 - 846 (4page)
이용수
초록· 키워드
오류제보하기
We report a case of intolerance to warfarin dosing due to impaired drug metabolism in a patient heterozygous for the CYP2C9*3 allele. A 30-year-old woman with an artificial cardiac pacemaker was taking warfarin to prevent thromboembolism. This patient had an extremely elevated international normalized ratio (INR) of prothrombin time (PT) following standard doses of warfarin and experienced difficulties during the induction of anticoagulation. Genotyping for CYP2C9 revealed that this patient was an intermediate metabolizer with genotype CYP2C9*1/*3. This case suggests the clinical usefulness of pharmacogenetic testing for individualized dosage adjustments of warfarin.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
/ / Human cytochrome P450 (CYP) genes. Available from
/ 1996 / Genetic analysis of the human cytochrome P450 CYP2C9 locus 6 : 429 ~ 39
/ 1997 / Allelic and functional variability of cytochrome P4502C9 7 : 51 ~ 8
/ 1997 / Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications 353 : 717 ~ 9
/ 1997 / Human P450 metabolism of warfarin 73 : 67 ~ 74
/ 1996 / Genetic analysis of the human cytochrome P450 CYP2C9 locus 6 : 429 ~ 39
/ 1997 / Allelic and functional variability of cytochrome P4502C9 7 : 51 ~ 8
/ 1997 / Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications 353 : 717 ~ 9
/ 1997 / Human P450 metabolism of warfarin 73 : 67 ~ 74
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