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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 249 - 257 (9page)
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초록· 키워드
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Objectives: The hepatotoxicity induced by Acetaminophen (AAP) mostly mediated by effect on oxidative stress parameters. The Zataria multiflora (Z.M) is an herbal medicine with well-known antioxidant effect. The aim of this study is investigation of preventive effects of Z.M and Carvacrol (CAR) on AAP-induced hepatotoxicity in rats. Methods: Rats were randomly divided into four groups including: 1) Control, 2) Acetaminophen (AAP), 3) and 4) CAR. The saline, Z.M (200 mg/kg) and CAR (20 mg/kg) were administrated orally for 6 days, after that AAP (600 mg/kg) was administrated in the 7th day. Blood sampling was performed on the first and last days. Also, the liver tissue was removed for evaluation of Malondyaldehide (MDA), Thiol content, Superoxide dismutase (SOD) and Catalase (CAT). Total Protein (tPro), Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Alkaline Phosphatase (ALP) in liver tissue were evaluated. The changes (Δ) of enzymes activities were presented. Results: The Δ GOT, Δ GPT and Δ ALP in CAR group significantly decreased compared to AAP group (P < 0.01 to P < 0.001) and Δ GPT in Z.M group was significantly reduced in comparison with AAP group (P < 0.05). Also, MDA, Thiol, SOD and CAT levels in treated groups were attenuated compared to AAP group (P < 0.05 to P < 0.001). Conclusion: Z.M and CAR have a powerful hepatoprotective effect. CAR is more effective than Z.M. Based on the results. Z.M and CAR could be potent supplementary agents against hepatotoxicity of AAP in patients.
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참고문헌 (54)
참고문헌 신청
Bechmann LP / 2012 / The interaction of hepatic lipid and glucose metabolism in liver diseases / J hepatol 56(4):952~964
Lee WM / 2003 / Drug-induced hepatotoxicity / New England J Med 349(5):474~485
Shah AD / 2011 / Understanding lactic acidosis in paracetamol(acetaminophen)poisoning / Br J clin pharmacol 71(1):20~28
Gyamlani GG / 2002 / Acetaminophen toxicity : suicidal vs accidental / Critical Care 6(2):155
Gunnell D / 2000 / Use of paracetamol(acetaminophen)for suicide and nonfatal poisoning : worldwide patterns of use and misuse / Suicide life threat behav 30(4):313~326
Lee WM / 2003 / Drug-induced hepatotoxicity / New England J Med 349(5):474~485
Shah AD / 2011 / Understanding lactic acidosis in paracetamol(acetaminophen)poisoning / Br J clin pharmacol 71(1):20~28
Gyamlani GG / 2002 / Acetaminophen toxicity : suicidal vs accidental / Critical Care 6(2):155
Gunnell D / 2000 / Use of paracetamol(acetaminophen)for suicide and nonfatal poisoning : worldwide patterns of use and misuse / Suicide life threat behav 30(4):313~326
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