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자료유형
학술저널
저자정보
조세훈 (김원묵기념 봉생병원) 제영묘 (김원묵기념 봉생병원) 장세헌 (김원묵기념 봉생병원) 이경환 (김원묵기념 봉생병원) 백대업 (김원묵기념봉생병원) 최진혁 (김원묵기념봉생병원)
저널정보
대한우울 조울병학회 우울조울병 우울조울병 제14권 제2호
발행연도
2016.1
수록면
87 - 91 (5page)

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Objectives : The effects of ADs usually appear several weeks treatment, and AAP augmentation can advance therapeutic responses in some patients. We performed a naturalistic, retrospective trial to compare early response and remission rates between AD treatment and AAP augmentation in real clinical practice. Methods : A retrospective chart review of patients with major depressive disorder without psychotic features and starting treatment for a new major depressive episode was conducted between January 2011 and July 2011. Hamilton Depression Rating Scale 17-item (HDRS-17) scores were collected at baseline, 2 weeks and 8±1 weeks after treatment. Response was defined as a ≥50% reduction from baseline HDRS-17 scores; remission was a score of ≤7. Results : Of 82 patients included, 31 were in the AD group and 51 were in the AAP augmentation group. In baseline, AAP augmentation group showed significantly higher HDRS-17 total score than AD group. At 2 & 8 weeks, however, there were no significant differences between two groups in response and remission rate. Conclusion : We could not prove superiority of AAP augmentation to AD treatment in response and remission rates of depression. However, considering higher baseline severity of AAP augmentation group, we can conclude AAP augmentation made a bigger decrease in HDRS-17 total score than AD group during 8-week treatment.

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