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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 68 - 72 (5page)
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Background: The effects of omega-3 polyunsaturated fatty acids (PUFAs) on cerebral vessels have not been clarified until now. Thus we investigated the efficacy of omega-3 PUFAs supplementation on cerebral blood flow velocity and vascular resistance via transcranial doppler (TCD). Methods: Consecutive twenty patients (13 male and 7 female) with at least 1 cerebrovascular risk factor or a known cerebrovascular disease were enrolled. Patients were treated with omega- 3 PUFAs (1 g, two times per day) for 12 weeks. Cerebral blood flow velocity, resistance index, and pulsatile index were checked before and after 12 weeks of treatment using TCD. Results: The change of resistance index in right MCA (from 0.58 ± 0.07 to 0.55 ± 0.07, p = 0.042) and left PCA (from 0.56 ± 0.07 to 0.53 ± 0.06, p = 0.037) showed significant improvement after 12 weeks of omega-3 PUFAs treatment. The changes in other vessels, however, failed to show any significant changes compared to the baseline. Conclusions: Omega-3 PUFAs treatment showed feasible efficacies for cerebral vascular resistances in this open label trial. To confirm these results, larger samples of patients and longer period of follow-up is warranted. (Korean J Clin Neurophysiol 2015;17:68-72)
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참고문헌 (20)
참고문헌 신청
Burr ML / 1989 / Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART) / Lancet 2 : 757 ~ 761
Chowdhury R / 2012 / Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease systematic review and meta-analysis / BMJ 345 :
Din JN / 2013 / Effect of w-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in male cigarette smokers / Heart 99 : 168 ~
Frauchiger B / 2001 / Comparison of carotid arterial resistive indices with intima-media thickness as sonographic markers of atherosclerosis / Stroke 32 : 836 ~ 841
GISSI-Prevenzione Investigators / 1999 / Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction:results of the GISSI-Prevenzio
Chowdhury R / 2012 / Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease systematic review and meta-analysis / BMJ 345 :
Din JN / 2013 / Effect of w-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in male cigarette smokers / Heart 99 : 168 ~
Frauchiger B / 2001 / Comparison of carotid arterial resistive indices with intima-media thickness as sonographic markers of atherosclerosis / Stroke 32 : 836 ~ 841
GISSI-Prevenzione Investigators / 1999 / Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction:results of the GISSI-Prevenzio
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