지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Sarcopenia is an age-related geriatric syndrome which is characterized by the gradual loss of muscle mass, muscle strength, and muscle quality. There are a lot of neurologic insults on sarcopenia at various levels from the brain to the neuromuscular junctions (NMJs) to generate a volitional task. Dopaminergic downregulation, inadequate motor programming and motor coordination impairment lead to decline of supraspinal drive. Motor unit reorganization and inflammatory changes in motor neuron decrease conduction velocity and amplitude of compound muscle action potential. Furthermore, NMJ remodeling and age related neurophysiological alterations may contribute to neuromuscular impairment. Sarcopenia is an age-associated, lifelong process which links to multiple etiological factors. Although not all the causes are completely understood, we suggest that compromised nervous system function may be one of the important contributors to the sarcopenia.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Bhanushali M / 2012 / Sarcopenia / John Wiley and Sons : 41 ~ 58
Bhasin S / 2003 / Testosterone supplementation for aging-associated sarcopenia / J Gerontol A Biol Sci Med Sci 58 : 1002 ~ 1008
Cham R / 2008 / Striatal dopaminergic denervation and gait in healthy adults / Exp Brain Res 185 : 391 ~ 398
Clark BC / 2008 / Sarcopenia =/= dynapenia / J Gerontol A Biol Sci Med Sci 63 : 829 ~ 834
Coxon JP / 2010 / Reduced basal ganglia function when elderly switch between coordinated movement patterns / Cereb Cortex 20 : 2368 ~ 2379
Bhasin S / 2003 / Testosterone supplementation for aging-associated sarcopenia / J Gerontol A Biol Sci Med Sci 58 : 1002 ~ 1008
Cham R / 2008 / Striatal dopaminergic denervation and gait in healthy adults / Exp Brain Res 185 : 391 ~ 398
Clark BC / 2008 / Sarcopenia =/= dynapenia / J Gerontol A Biol Sci Med Sci 63 : 829 ~ 834
Coxon JP / 2010 / Reduced basal ganglia function when elderly switch between coordinated movement patterns / Cereb Cortex 20 : 2368 ~ 2379
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