지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Sarcopenia leads to loss of skeletal muscle mass, quality, and strength due to aging; it was recently given a disease code (International Classification of Diseases, Tenth Revision, Clinical Modification, M62.84). As a result, in recent years, sarcopenia-related research has increased. In addition, various studies seeking to prevent and treat sarcopenia by identifying the various mechanisms related to the reduction of skeletal muscle properties have been conducted. Previous studies have identified muscle synthesis and breakdown; investigating them has generated evidence for preventing and treating sarcopenia. Mouse models are still the most useful ones for determining mechanisms underlying sarcopenia through correlations and interventions involving specific genes and their phenotypes. Mouse models used to study sarcopenia often induce muscle atrophy by hindlimb unloading, denervation, or immobilization. Though it is less frequently used, the senescence-accelerated mouse can also be useful for sarcopenia research. Herein, we discuss cases where senescence-accelerated and genetically engineered mouse models were used in sarcopenia research and different perspectives to use them.
목차
등록된 정보가 없습니다.
참고문헌 (78)
참고문헌 신청
Ian Janssen / 2010 / Evolution of sarcopenia research / Applied Physiology, Nutrition, and Metabolism 35(5):707~712
Kyung-Wan Baek / 2020 / Rodent Model of Muscular Atrophy for Sarcopenia Study / 대한골대사학회지 27(2):97~110
Wim Derave / 2005 / Soleus muscles of SAMP8 mice provide an accelerated model of skeletal muscle senescence / Experimental Gerontology 40(7):562~572
T TAKEDA / 1981 / A new murine model of accelerated senescence / Mechanisms of Ageing and Development 17(2):183~194
Toshio Takeda / 1994 / A novel murine model of aging, Senescence-Accelerated Mouse (SAM) / Archives of Gerontology and Geriatrics 19(2):185~192
Kyung-Wan Baek / 2020 / Rodent Model of Muscular Atrophy for Sarcopenia Study / 대한골대사학회지 27(2):97~110
Wim Derave / 2005 / Soleus muscles of SAMP8 mice provide an accelerated model of skeletal muscle senescence / Experimental Gerontology 40(7):562~572
T TAKEDA / 1981 / A new murine model of accelerated senescence / Mechanisms of Ageing and Development 17(2):183~194
Toshio Takeda / 1994 / A novel murine model of aging, Senescence-Accelerated Mouse (SAM) / Archives of Gerontology and Geriatrics 19(2):185~192
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