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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.23 No.3
- 발행연도
- 2019.1
- 수록면
- 98 - 104 (7page)
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초록· 키워드
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Sarcopenia, the loss of skeletal muscle mass and function with age, was first recognized as a disease in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) (M62.84) and has recently attracted attention as aged populations increase. However, the diagnostic criteria for sarcopenia remain controversial and there are as yet no US Food and Drug Administration-approved medications for sarcopenia. Given that both intrinsic and extrinsic factors contribute to sarcopenia onset and development, understanding the mechanism of sarcopenia is important for the development of therapeutic strategies. In this review, we described a variety of drugs for sarcopenia under investigation, including myostatin/ActR2 signaling inhibitors, exercise mimetics, anabolic hormones, and natural compounds. However, the combination of non-drug therapies with exercise and nutritional supplements are also needed as more easily accessible intervention strategies against sarcopenia rather than pharmacological treatments alone. Many approaches to develop therapeutic methods to overcome sarcopenia may lead to healthy aging.
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참고문헌 (53)
참고문헌 신청
Rosenberg IH / 1997 / Sarcopenia: origins and clinical relevance / J Nutr 127(5 Suppl):990S~991S
McGregor RA / 2014 / It is not just muscle mass: a review of muscle quality, composition and me-tabolism during ageing as determinants of muscle function and mobility in later life / Longev Healthspan 3:9
Lang T / 2010 / Sarcopenia: etiology, clinical consequences, intervention, and assessment / Osteoporos Int 21:543~559
Cao L / 2016 / Sarcopenia is recognized as an independent condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) code / J Am Med Dir Assoc 17:675~677
Dennison EM / 2017 / Epidemiology of sarcope-nia and insight into possible therapeutic targets / Nat Rev Rheu-matol 13:340~347
McGregor RA / 2014 / It is not just muscle mass: a review of muscle quality, composition and me-tabolism during ageing as determinants of muscle function and mobility in later life / Longev Healthspan 3:9
Lang T / 2010 / Sarcopenia: etiology, clinical consequences, intervention, and assessment / Osteoporos Int 21:543~559
Cao L / 2016 / Sarcopenia is recognized as an independent condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) code / J Am Med Dir Assoc 17:675~677
Dennison EM / 2017 / Epidemiology of sarcope-nia and insight into possible therapeutic targets / Nat Rev Rheu-matol 13:340~347
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