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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 127 - 133 (7page)
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Background: Skeletal muscle is a major target of thyroid hormone action. Although sarcopenia is associated with adverse health outcomes in the elderly, few studies have examined the association between sarcopenia and thyroid hormone levels in elderly Asians. We investigated the relationship between thyroid hormone levels and sarcopenia in elderly Koreans. Methods: 658 individuals (324 males and 334 females) 60 years old who visited the Health Screening and Promotion Center at Ajou University Hospital were recruited for the study. Whole-body dual-energy X-ray absorptiometry was performed, and gait speed and hand grip strength were measured. The rate and odds ratios for sarcopenia were calculated for free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels. Results: The fT4 concentration was negatively associated with muscle mass in males (r2 ¼ 0.031, p ¼ 0.001) and females (r2 ¼ 0.019, ps ¼ 0.011). The highest rate of sarcopenia occurred in the highest fT4 quartile in males and females. However, no significant differences were found among TSH quartiles in either sex. TSH was not significantly associated with the risk of sarcopenia in males or females, whereas the fT4 concentration was associated with the risk of sarcopenia in both sexes. Conclusions: Higher fT4 levels, not lower TSH levels might have an adverse effect on sarcopenia especially in elderly people.
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참고문헌 (26)
참고문헌 신청
OECD / Ageing trends in regions and cities
Tunbridge WM / 1977 / The spectrum of thyroid disease in a community: the Whickham Survey / Clin Endocrinol Oxf 7:481~493
Vanderpump MP / 1995 / The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey / Clin Endocrinol Oxf 43:55~68
Boelaert K / 2013 / Thyroid dysfunction in the elderly / Nat Rev Endocrinol 9:194~204
Kramer C / 2009 / Treated hypothyroidism, cognitive function, and depressed mood in old age: the Rancho Bernardo Study / Eur J Endocrinol 161:917~921
Tunbridge WM / 1977 / The spectrum of thyroid disease in a community: the Whickham Survey / Clin Endocrinol Oxf 7:481~493
Vanderpump MP / 1995 / The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey / Clin Endocrinol Oxf 43:55~68
Boelaert K / 2013 / Thyroid dysfunction in the elderly / Nat Rev Endocrinol 9:194~204
Kramer C / 2009 / Treated hypothyroidism, cognitive function, and depressed mood in old age: the Rancho Bernardo Study / Eur J Endocrinol 161:917~921
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