Diabetic Peripheral Neuropathy as a Risk Factor for Sarcopenia

Tae Jung Oh; Yoojung Song; Jae Hoon Moon; Sung Hee Choi; Hak Chul Jang

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자료유형: 학술저널

저자정보: Tae Jung Oh (Seoul National University Bundang Hospital) Yoojung Song (Seoul National University Bundang Hospital) Jae Hoon Moon (Seoul National University Bundang Hospital) Sung Hee Choi (Seoul National University Bundang Hospital) Hak Chul Jang (Seoul National University Bundang Hospital)

저널정보: 대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.23 No.4

발행연도: 2019.1

수록면: 170 - 175 (6page)

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Background: Diabetic peripheral neuropathy (DPN) is prevalent in patients with type 2 diabetes, and its prevalence increases with age. A previous study demonstrated the association between DPN and muscle dysfunction; however, there are limited data on the association between DPN and sarcopenia. Methods: We enrolled participants with type 2 diabetes and measured hand grip strength (HGS), lean body mass using a bio-impedance analysis, and gait speed using a 4-m walking test. Sarcopenia was diagnosed according to the criteria from the Asian Working Group for Sarcopenia. We also performed various examinations of neuropathy, including both small- and large-fiber neuropathy. Results: Among 170 participants (mean age, 61.5±6.6 years), 24 (14.1%) were diagnosed with sarcopenia. The Michigan Neuropathy Screening Instrument Questionnaire (MNSI-Q) scores were higher in subjects with sarcopenia than in those without sarcopenia (2.7±1.3 vs. 2.4±1.3; p=0.008). However, other neuropathy examination results were not significantly associated with sarcopenia. The MNSI-Q score was negatively associated with HGS, with an odds ratio (OR) of 1.367 (95% confidence interval [CI], 1.122–1.667) in predicting the presence of sarcopenia. After adjusting for sex, body mass index, and diabetes duration, the MNSI-Q score was associated with the presence of sarcopenia (adjusted OR=1.310; 95% CI, 1.041–1.647). Conclusion: In this population with type 2 diabetes, patients with sarcopenia had higher neuropathy questionnaire scores than those without sarcopenia. Therefore, active screening for sarcopenia should be performed in subjects with DPN.

#Sarcopenia #Diabetic neuropathy #Skeletal muscle #Muscle strength

참고문헌 (25)

참고문헌 신청

Park SW / 2009 / Excessive loss of skeletal muscle mass in older adults with type 2 diabetes / Diabetes Care 32:1993~1997

Kim TN / 2010 / Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS) / Diabetes Care 33:1497~1499

장학철 / 2016 / Sarcopenia, Frailty, and Diabetes in Older Adults / Diabetes and Metabolism Journal 40(3):182~189

윤지완 / 2016 / Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging / Diabetes and Metabolism Journal 40(2):140~146

Tajiri Y / 2010 / Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors / Metab Syndr Relat Disord 8:137~142

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