지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: The purpose of this study was to find out the cause of discrepancy between various automated immunoassays for 25-hydroxy-vitamin D (25-[OH]D). Methods: National Institute of Standards & Technology Standard Reference Material (SRM) 972a is SRM for 25-(OH)D and consists of 4 vials of frozen serum with different concentrations of 25-(OH)D. Each concentration was measured 6 times in 3 different immunoassays: AD- VIA Vitamin D Total assay (Siemens Healthcare, Erlangen, Germany), ARCHITECT 25-(OH) D (Abbott Laboratories, Abbott Park, IL, USA), and COBAS Vitamin D Total assay (Roche Diagnostics, Basel, Switzerland). Results: When using the certified reference values of SRM 972a as it is, discarding the cross-reactivity of each immunoassay, for ADVIA, the coefficient of determination (R2 ) as a score of regression analysis was 0.8995 and maximal difference between measured value and certified reference value was 3.6 ng/mL in level 3. The R2 and maximal differences of ARCHITECT were 0.5377 and 6.9 ng/mL, respectively, in level 4. Those of COBAS were 0.3674 and 22.3 ng/mL, respectively, in level 4. When considering cross-reactivities of each immunoassays to various 25-(OH)D metabolites, the ADVIA had R2 and maximal difference of 0.9254 and 3.3 ng/mL, respectively, in level 3. For ARCHITECT, the R2 and maximal differences were 0.7602 and 5.1 ng/ mL, respectively, in level 1. Those of COBAS were 0.9284 and 4.9 ng/mL, respectively, in level 1. Conclusions: The cause of discrepancies between vitamin D immunoassays was mainly on the difference in cross-reactivities to various vitamin D metabolites. The discrepancies can be considerably decreased by considering cross-reactivities of each immunoassay.
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참고문헌 (21)
참고문헌 신청
Bentley J. / 2015 / The role of vitamin D in infants, children and young people / Nurs Child Young People 27 : 28 ~ 35
Brown AJ / 1999 / 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha, 25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion / J C
Carter GD / 2011 / Accuracy of 25-hydroxyvitamin D assays: confronting the issues / Curr Drug Targets 12 : 19 ~ 28
Farrell C / 2012 / 25-Hydroxyvitamin D testing : challenging the performance of current automated immunoassays / Clin Chem Lab Med 50 : 1953 ~ 1963
Farrell CJ / 2012 / State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography-tandem mass spectrometry methods / Clin Chem 58 : 531
Brown AJ / 1999 / 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha, 25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion / J C
Carter GD / 2011 / Accuracy of 25-hydroxyvitamin D assays: confronting the issues / Curr Drug Targets 12 : 19 ~ 28
Farrell C / 2012 / 25-Hydroxyvitamin D testing : challenging the performance of current automated immunoassays / Clin Chem Lab Med 50 : 1953 ~ 1963
Farrell CJ / 2012 / State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography-tandem mass spectrometry methods / Clin Chem 58 : 531
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