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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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GSK3β is an important kinase that functions in cellular signaling pathways. Morin, a flavonoid that is plentiful in nature, wasfound as an inhibitor of GSK3β that can reduce tau pathology in vivo and in vitro. To identify how morin inhibits GSK3β,GSK3β protein was overexpressed and purified using affinity and ion exchange chromatography. GSK3β protein wascrystallized with morin using hanging drop vapor diffusion method in the presence of 18 % (v/v) PEG 4000, 100 mM sodiumcitrate (pH 6.5), and 5 % (v/v) 2-propanol at 290 K. X-ray diffraction data was collected to a maximum resolution of 2.14 Å. The crystal belonged to P21, with unit cell parameters a = 67.6 Å, b = 134.4 Å, c = 100.4 Å, α = γ = 90.0°, β = 103.8°.
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참고문헌 (16)
참고문헌 신청
Ali, A / 2001 / Glycogen synthase kinase-3 : properties, functions, and regulation / Chem Rev 101:2527~2540
Chung, S. S / 2016 / Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase / Int J Oncol 49:487~498
Emsley, P / 2004 / Coot : model-building tools for molecular graphics / Acta Crystallogr D Biol Crystallogr 60:2126~2132
Gong, E. J / 2011 / Morin attenuates tau hyperphosphorylation by inhibiting GSK3beta / Neurobiol Dis 44:223~230
Hemachandra Reddy, P / 2013 / Amyloid beta-induced Glycogen Synthase Kinase 3βPhosphorylated VDAC1 in Alzheimer’s / Implications for Synaptic Dysfunction and Neuronal Damage. Biochim Biophys Acta 1832, 1913-1921
Chung, S. S / 2016 / Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase / Int J Oncol 49:487~498
Emsley, P / 2004 / Coot : model-building tools for molecular graphics / Acta Crystallogr D Biol Crystallogr 60:2126~2132
Gong, E. J / 2011 / Morin attenuates tau hyperphosphorylation by inhibiting GSK3beta / Neurobiol Dis 44:223~230
Hemachandra Reddy, P / 2013 / Amyloid beta-induced Glycogen Synthase Kinase 3βPhosphorylated VDAC1 in Alzheimer’s / Implications for Synaptic Dysfunction and Neuronal Damage. Biochim Biophys Acta 1832, 1913-1921
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