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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 525 - 537 (13page)
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초록· 키워드
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Stem cells include a diverse number of toti-, pluri-, and
multi-potent cells that play important roles in cellular
genesis and differentiation, tissue development, and
organogenesis. Genetic regulation involving various
transcription factors results in the self-renewal and differentiation
properties of stem cells. The nuclear receptor
(NR) superfamily is composed of 48 ligand-activated
transcription factors involved in diverse physiological
functions such as metabolism, development,
and reproduction. Increasing evidence shows that certain
NRs function in regulating stemness or differentiation
of embryonic stem (ES) cells and tissue-specific
adult stem cells. Here, we review the role of the NR
superfamily in various aspects of stem cell biology, including
their regulation of stemness, forward- and
trans-differentiation events; reprogramming of terminally
differentiated cells; and interspecies differences.
These studies provide insights into the therapeutic potential
of the NR superfamily in stem cell therapy and
in treating stem cell-associated diseases (e.g., cancer
stem cell).
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aberg E / 2008 / Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus / Hippocampus 18 : 785 ~ 792
Akamatsu W / 2009 / Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage / J Neurosci
Akiyama H / 1996 / 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5 / J Bone Miner Res 11 : 22 ~ 28
Akune T / 2004 / PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors / J Clin Invest 113 : 846 ~ 855
Ambrogini P / 2005 / Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat / Neuroendocrinology 81 : 244 ~ 253
Akamatsu W / 2009 / Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage / J Neurosci
Akiyama H / 1996 / 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5 / J Bone Miner Res 11 : 22 ~ 28
Akune T / 2004 / PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors / J Clin Invest 113 : 846 ~ 855
Ambrogini P / 2005 / Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat / Neuroendocrinology 81 : 244 ~ 253
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