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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 782 - 792 (11page)
이용수
초록· 키워드
오류제보하기
Intraportal islet transplantation (IPIT) may potentially cure Type 1 diabetes mellitus; however, graft failure in the early post-transplantation period presents a major obstacle. In this study, we tested the ability of nicotinamide to prevent early islet destruction in a syngeneic mouse model. Mice (C57BL/6) with chemically- induced diabetes received intraportal transplants of syngeneic islet tissue in various doses. Islets were cultured for 24 h in medium with or without 10 mM nicotinamide supplementation. Following IPIT, islet function was confirmed by an intraperitoneal glucose tolerance test (IPGTT) and hepatectomy. The effects of nicotinamide were evaluated by blood glucose concentration, serum monocyte chemoattractant protein- 1 (MCP-1) concentration, and immunohistology at 3 h and 24 h after IPIT. Among the various islet doses, an infusion of 300 syngeneic islets treated with nicotinamide exhibited the greatest differences in glucose tolerance between recipients of treated and untreated (i.e., control) islets. One day after 300 islet equivalent (IEQ) transplantation, islets treated with nicotinamide were better granulated than the untreated islets (P = 0.01), and the recipients displayed a slight decrease in serum MCP-1 concentration, as compared to controls. After 15 days, recipients of nicotinamide- pretreated islets showed higher levels of graft function (as measured by IPGTT) than controls.
The pretreatment also prolonged graft survival (＞ 100 days) and function; these were confirmed by partial hepatectomy, which led to the recurrence of diabetes.
Pretreatment of islet grafts with nicotinamide may prevent their deterioration on the early period following IPIT in a syngeneic mouse model.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Andersen HU / 1994 / Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans / Diabetes 43 : 770 ~
Andrades P / 2007 / Insulin secretion from pancreatic islets in fibrin glue clots at different fibrinogen and thrombin concentrations / Transplant Proc 39 : 1607 ~ 1608
Beattie GM / 2002 / A novel approach to increase human islet cell mass while preserving β-cell function / Diabetes 51 : 3435 ~ 3439
Berman DM / 2007 / Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model / Transplantation 84 : 308 ~ 315
Buscema M / 1992 / Nicotinamide partially reverses the interleukin-1 beta inhibition of glucose-induced insulin release in pancreatic islets / Metabolism 41 : 296 ~ 300
Andrades P / 2007 / Insulin secretion from pancreatic islets in fibrin glue clots at different fibrinogen and thrombin concentrations / Transplant Proc 39 : 1607 ~ 1608
Beattie GM / 2002 / A novel approach to increase human islet cell mass while preserving β-cell function / Diabetes 51 : 3435 ~ 3439
Berman DM / 2007 / Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model / Transplantation 84 : 308 ~ 315
Buscema M / 1992 / Nicotinamide partially reverses the interleukin-1 beta inhibition of glucose-induced insulin release in pancreatic islets / Metabolism 41 : 296 ~ 300
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