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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 739 - 748 (10page)
이용수
초록· 키워드
오류제보하기
Nonspecific inflammatory response is the major cause for failure of islet grafts at the early phase of intraportal islet transplantation (IPIT). Bilirubin, a natural product of heme catabolism, has displayed anti-oxidative and anti-inflammatory activities. The present study has demonstrated that bilirubin protected islet grafts by inhibiting nonspecific inflammatory response in a syngeneic rat model of IPIT. The inflammation-induced cell injury was mimicked by exposing cultured rat insulinoma INS-1 cells to cytokines (IL-1β, TNF-α and IFN-γ) in in vitro assays. At appropriate lower concentrations,bilirubin significantly attenuated the reduced cell viability and enhanced cell apoptosis induced by cytokines, and protected the insulin secretory function of INS-1 cells. Diabetic inbred male Lewis rats induced by streptozotocin underwent IPIT at different islet equivalents (IEQs) (optimal dose of 1000, and suboptimal doses of 750 or 500), and bilirubin was administered to the recipients every 12 h, starting from one day before transplantation until 5 days after transplantation. Administration of bilirubin improved glucose control and enhanced glucose tolerance in diabetic recipients, and reduced the serum levels of inflammatory mediators including IL-1β, TNF-α, soluble intercellular adhesion molecule 1, monocyte chemoattractant protein-1 and NO, and inhibited the infiltration of Kupffer cells into the islet grafts, and restored insulin-producing ability of transplanted islets.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Amoli MM / 2006 / Would blockage of cytokines improve the outcome of pancreatic islet transplantation? / Med Hypotheses 66 : 816 ~ 819
Arita S / 1998 / Prevention of primary islet isograft nonfunction in mice with pravastatin / Transplantation 65 : 1429 ~ 1433
Biarnes M / 2002 / Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia / Diabetes 51 : 66 ~ 72
Bottino R / 1998 / Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation / Di
Cantaluppi V / 2006 / Camussi G. Antiangiogenic and immunomodulatory effects of rapamycin on islet endothelium: relevance for islet transplantation / Am J Transplant 6 : 2601
Arita S / 1998 / Prevention of primary islet isograft nonfunction in mice with pravastatin / Transplantation 65 : 1429 ~ 1433
Biarnes M / 2002 / Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia / Diabetes 51 : 66 ~ 72
Bottino R / 1998 / Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation / Di
Cantaluppi V / 2006 / Camussi G. Antiangiogenic and immunomodulatory effects of rapamycin on islet endothelium: relevance for islet transplantation / Am J Transplant 6 : 2601
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노팔천연복합물이 Streptozotocin으로 유발된 당뇨 쥐의 혈당 및 췌장조직에 미치는 영향
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Introduction of Saxicolous Lichens Distributed in Coastal Rocks of U-do Islet in Jeju, Korea
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