지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 149 - 159 (11page)
이용수
초록· 키워드
오류제보하기
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpeni-cillamine-induced apoptotic cell death via the in-hibition of mitochondrial membrane potential dis-ruption and cytochrome c re lease in RINm5F (RIN) rat insulinoma cells. In this study, the preventive effects of CRE against cytokine-induced β-cell death was assessed. Cytokines generated by immune cells infiltrating pancreatic islets are crucial mediators of β-cell destruction in insulin-dependent diabetes mellitus. The treatment of RIN cells with IL-1β and IFN-γ resulted in a reduction of cell viability. CRE completely protected IL-1β and IFN-γ-mediated cell death in a concentration-dependent manner. Incu-bation with CRE induced a significant suppression of IL-1β and IFN-γ-induced nitric oxide (NO) production, a finding which correlated well with reduced levels of the iNOS mRNA and protein. The molecular mecha-nism by which CRE inhibited iNOS gene expression appeared to involve the inhibition of NF-κB activa-tion. The IL-1β and IFN-γ-stimulated RIN cells showed increases in NF-κB binding activity and p65 subunit levels in nucleus, and I κBα degradation in cytosol compared to unstimulated cells. Furthermore, the protective effects of CRE were verified via the observation of reduced NO generation and iNOS expression, and normal insulin-secretion res-ponses to glucose in IL-1 β and IFN-γ-treated islets.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ / Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 : 248
/ / Eizirik DL. TNF- and IFN- potentiate the deleterious effects of IL-1 on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 1994 : 399 ~ 406
Amoah-Apraku B / 1995 / NF-B and transcriptional control of renal epithelial-inducible nitric oxide synthase 48 : 674 ~ 682
Baeuerle PA / / Henkel T. Function and activation of NF-B in the immune system. Annu Rev Immunol 1994 : 141 ~ 79
Baldwin AS Jr / 1996 / The NF-B and I B proteins: new discoveries and insights 14 : 649 ~ 683
/ / Eizirik DL. TNF- and IFN- potentiate the deleterious effects of IL-1 on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 1994 : 399 ~ 406
Amoah-Apraku B / 1995 / NF-B and transcriptional control of renal epithelial-inducible nitric oxide synthase 48 : 674 ~ 682
Baeuerle PA / / Henkel T. Function and activation of NF-B in the immune system. Annu Rev Immunol 1994 : 141 ~ 79
Baldwin AS Jr / 1996 / The NF-B and I B proteins: new discoveries and insights 14 : 649 ~ 683
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic β-cell damage
Experimental and Molecular Medicine
2003 .01
-
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post- translational modification of IκB
Experimental and Molecular Medicine
2004 .01
-
B CELL DIVISIONS IN T CELL DEPENDENT B CELL REACTION
한국미생물학회 학술대회논문집
1997 .04
-
The efficacy of SPA0355 in protecting b cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
Experimental and Molecular Medicine
2013 .01
-
Addition of an N-Terminal Poly-Glutamate Fusion Tag Improves Solubility and Production of Recombinant TAT-Cre Recombinase in Escherichia coli
Journal of Microbiology and Biotechnology
2020 .01
-
Production of Cellulases by Rhizopus stolonifer from Glucose-Containing Media Based on the Regulation of Transcriptional Regulator CRE
Journal of Microbiology and Biotechnology
2017 .01
-
The stimulatory effect of IL-1β on the insulin secretion of rat pancreatic islet is not related with iNOS pathway
Experimental and Molecular Medicine
2002 .01
-
B cell-associated immune profiles in patients with end-stage renal disease (ESRD)
Experimental and Molecular Medicine
2012 .01
-
들깨 새싹 추출물의 췌장 RINm5F 세포에서 NF-κB 경로를 통한 사이토카인에 의한 손상 예방 효과
생명과학회지
2017 .05
-
Sulfuretin protects against cytokine-induced β-cell damage and prevents streptozotocin-induced diabetes
Experimental and Molecular Medicine
2010 .01
-
Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes
Experimental and Molecular Medicine
2015 .01
-
블루베리가 인체 유방암세포 MCF7에서 세포 사멸 관련 유전자 발현에 미치는 영향
동아시아식생활학회지
2010 .02
-
Cellular and Biochemical Alterations in L6 Myoblast Cells Induced by 6-Aminonicotinamide
Integrative biosciences
2007 .01
-
Bilirubin protects grafts against nonspecific inflammationinduced injury in syngeneic intraportal islet transplantation
Experimental and Molecular Medicine
2010 .01
-
Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet b cells
Experimental and Molecular Medicine
2013 .01
-
Cell Death and Bacterial Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2013 .06
-
Quercetin Prevents Hydrogen Peroxide-induced Necrotic and Apoptotic Cell Death in Human Colonic Epithelial Cells
대한임상검사과학회지
2011 .01
-
Effects of a Tetramethoxyhydroxyflavone p7F on the Expression of Inflammatory Mediators in LPS-treated Human Synovial Fibroblast and Macrophage Cells
Journal of Microbiology and Biotechnology
2008 .01
-
Induction of nitric oxide synthase (NOS) by soluble glucocorticoid induced tumor necrosis factor receptor (sGITR) is modulated by IFN-γ in murine macrophage
Experimental and Molecular Medicine
2003 .01
-
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
Experimental and Molecular Medicine
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0