지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 628 - 638 (11page)
이용수
초록· 키워드
오류제보하기
NF-κB activation has been implicated as a key signaling mechanism for pancreatic β-cell damage. Sulfuretin is one of the main flavonoids produced by Rhus verniciflua,which is reported to inhibit the inflammatory response by suppressing the NF-κB pathway.
Therefore, we isolated sulfuretin from Rhus verniciflua and evaluated if sulfuretin could inhibit cytokine- or streptozotocin-induced β-cell damage. Rat insulinoma RINm5F cells and isolated rat islets were treated with IL-1β and IFN-γ to induce cytotoxicity. Incubation of cells and islets with sulfuretin resulted in a significant reduction of cytokine-induced NF-κB activation and its downstream events, iNOS expression, and nitric oxide production. The cytotoxic effects of cytokines were completely abolished when cells or islets were pretreated with sulfuretin. The protective effect of sulfuretin was further demonstrated by normal insulin secretion of cytokine-treated islets in response to glucose. Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was further evidenced by immunohistochemical staining of islets. However, the diabetogenic effects of streptozotocin were completely prevented when mice were pretreated with sulfuretin. The anti-diabetogenic effects of sulfuretin were also mediated by suppression of NF-κB activation. Collectively, these results indicate that sulfuretin may have therapeutic value in preventing β-cell damage.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adcock IM / 1994 / Oxidative stress induces NFκB DNA binding and inducible NOS mRNA in human epithelial cells / Biochem Biophys Res Commun 199 : 1518 ~ 1524
Arnush M / 1998 / IL-1 produced and released endogenously within human islets inhibits β cell function / J Clin Invest 02 : 516 ~ 526
Bedoya FJ / 1995 / Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells / Biochem Bioph
Chang I / 2003 / Nuclear factor κB protects pancreatic β-cells from tumor necrosis factor-α-mediated apoptosis / Diabetes 52 : 1169 ~ 1175
Cnop M / 2005 / Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities / Diabetes 54 (2) : S97 ~ S107
Arnush M / 1998 / IL-1 produced and released endogenously within human islets inhibits β cell function / J Clin Invest 02 : 516 ~ 526
Bedoya FJ / 1995 / Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells / Biochem Bioph
Chang I / 2003 / Nuclear factor κB protects pancreatic β-cells from tumor necrosis factor-α-mediated apoptosis / Diabetes 52 : 1169 ~ 1175
Cnop M / 2005 / Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities / Diabetes 54 (2) : S97 ~ S107
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
옻나무 목부로부터 분리한 Favonoids가 Paraquat 독성의 경감기전 검색
생명과학회지
2003 .12
-
The efficacy of SPA0355 in protecting b cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
Experimental and Molecular Medicine
2013 .01
-
Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic β-cell damage
Experimental and Molecular Medicine
2003 .01
-
Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes
Experimental and Molecular Medicine
2015 .01
-
Coptidis rhizoma extract protects against cytokine-induceddeath of pancreatic β-cells through suppression of NF-κBactivation
Experimental and Molecular Medicine
2007 .01
-
Bilirubin protects grafts against nonspecific inflammationinduced injury in syngeneic intraportal islet transplantation
Experimental and Molecular Medicine
2010 .01
-
Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice
Experimental and Molecular Medicine
2014 .01
-
Regulatory T Cells Promote Pancreatic Islet Function and Viability via TGF-1 in vitro and in vivo
대한임상검사과학회지
2018 .01
-
Cytokine 과 그 역할 ( Cytokine and Role )
생명과학
1993 .07
-
Effect of nicotinamide on early graft failure following intraportal islet transplantation
Experimental and Molecular Medicine
2009 .01
-
간섬유화 동물에서 옻나무 목부로부터 분리한 flavonoids의 독성 경감기전
생명과학회지
2002 .06
-
Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice
Experimental and Molecular Medicine
2003 .01
-
Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
Experimental and Molecular Medicine
2005 .01
-
들깨 새싹 추출물의 췌장 RINm5F 세포에서 NF-κB 경로를 통한 사이토카인에 의한 손상 예방 효과
생명과학회지
2017 .05
-
The stimulatory effect of IL-1β on the insulin secretion of rat pancreatic islet is not related with iNOS pathway
Experimental and Molecular Medicine
2002 .01
-
저강도 treadmill 운동이 streptozotocin 유도 당뇨쥐의 혈당, 인슐린 및 지질 농도에 미치는 영향
생명과학회지
2004 .04
-
Signal Transduction of the Cytokine Receptor
Korean journal of biological sciences
1998 .01
-
β-Lapachone suppresses radiation-induced activation of nuclear factor-κB
Experimental and Molecular Medicine
2010 .01
-
Immune-Enhancing Effect of Nanometric Lactobacillus plantarum nF1 (nLp-nF1) in a Mouse Model of Cyclophosphamide-Induced Immunosuppression
Journal of Microbiology and Biotechnology
2018 .01
-
Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IκBα in TNFα-stimulated HEK293 cells
Experimental and Molecular Medicine
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0