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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 261 - 268 (8page)
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초록· 키워드
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Mouse embryonic stem (mES) cells are capable of undergoing chondrogenesis in vitro. To en-hance this proces, the human SOX9 (hSOX9) cDNA was delivered into mES cels and the clones overexpressing hSOX9 (denoted as mES-hSOX9 cells) were verified by Western blot analysis. The grecan and Pax1 were expressed in mES-hSOX9 cells grown on feeder layers, sugesting the im-mediate efect of exogenous SOX9 on chondro-genesis. However, SOX9 overexpression did not afect the cel cycle distribution in undiferentia-ted mES cells. Upon diferentiation, colagen IIB (an adult form) was detected in day 3 imature embryoid bodies. In adition, the overexpression of exogenous SOX9 significantly induced trans-criptional activity driven by SOX9 binding site. Taken together, we for the first time demon-enous SOX9 in undiferentiated mES cels might have dual potentials to induce both chondrogenic comitment and growth capacity in the undif-ferentiated status.
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참고문헌 (28)
참고문헌 신청
/ / Cartilage-derived morphogenetic protein-1 promotes thedifferentiation of mesenchymal stem cells into chondrocytes 325 : 453 ~ 460
/ / Exrpession of human bone morphogenic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2cells induces differentiation into distinct mesenchymal celllineages : 871
/ / Isolation of a pluripotent cell line from earlymouse embryos cultured in medium conditioned by teratocarcinomastem cells : 7634 ~ 8
/ 198 / de Crombrugghe B. Chondrocyte-specific enhancer elements in the col11a2 generesemble the col2a1 tissue-specifc enhancer : 14998 ~ 15006
/ 1995 / Embroynic stem cells express neuronal properties in vitro 168 : 342 ~ 357
/ / Exrpession of human bone morphogenic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2cells induces differentiation into distinct mesenchymal celllineages : 871
/ / Isolation of a pluripotent cell line from earlymouse embryos cultured in medium conditioned by teratocarcinomastem cells : 7634 ~ 8
/ 198 / de Crombrugghe B. Chondrocyte-specific enhancer elements in the col11a2 generesemble the col2a1 tissue-specifc enhancer : 14998 ~ 15006
/ 1995 / Embroynic stem cells express neuronal properties in vitro 168 : 342 ~ 357
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