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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제4호
- 발행연도
- 2004.1
- 수록면
- 693 - 697 (5page)
이용수
초록· 키워드
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YH-1715R, (2R,3R)-2-(2,4-difluorophenyl)-3-(3-methoxy-1,2,4-isothiazol-3-yl-thio)-1-(1H-1,2,4-triazol-1-yl)-2-butanol, a new triazole derivative obtained by thestructural modification of fluconazole, was found to exhibitpotent anti-Candida activity against a wide variety ofCandida albicans (C. albicans) (MIC: 0.4- 12.5 mg/l). Toinvestigate the mode of action of YH-1715R, its effect onergosterol biosynthesis in cell-free extracts and whole cells ofC. albicans was examined. The inhibitory activity of YH-1715R was approximately ten-fold higher than that offluconazole. To determine the primary action mechanism ofYH-1715R, its inhibitory activity against lanosterol 14α-demethylase (14α-DM), a major target for azole, wasmeasured using gas-liquid chromatography. YH-1715R andfluconazole were found to inhibit 14α-DM with an IC50 of0.015 μM and 0.018 μM, respectively, plus the mode ofinhibition of YH-1715R and fluconozole was noncompetitivewith a Ki of 0.0533 μM and 0.0975 μM.
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참고문헌 (11)
참고문헌 신청
Groll / 2001 / Uncommon opportunisticfungi: New nosocomial threats : 8 ~ 24
Hitchcock / 1990 / Interaction of azole antifungalantibiotics with cytochrome P-450-dependent 14α-steroldemethylase purified from Candida albicans : 475 ~ 480
Lamb / 1997 / Differentialinhibition of Candida albicans CYP51 by stereoisomers ofazole antifungals 149 : 23 ~ 30
Lee / 1999 / Biochemical basis for a cholesterol-lowering activityof 2-[2''-(1'',3''-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro-2H-1-benzopyran (SKP-450) a novel
National Committee for Clinical Laboratory Standards / 1997 / National Committee for Clinical Laboratory Standards Reference Method for Broth Dilution Antifungal Susceptibili
Hitchcock / 1990 / Interaction of azole antifungalantibiotics with cytochrome P-450-dependent 14α-steroldemethylase purified from Candida albicans : 475 ~ 480
Lamb / 1997 / Differentialinhibition of Candida albicans CYP51 by stereoisomers ofazole antifungals 149 : 23 ~ 30
Lee / 1999 / Biochemical basis for a cholesterol-lowering activityof 2-[2''-(1'',3''-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro-2H-1-benzopyran (SKP-450) a novel
National Committee for Clinical Laboratory Standards / 1997 / National Committee for Clinical Laboratory Standards Reference Method for Broth Dilution Antifungal Susceptibili
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