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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제7호
- 발행연도
- 2015.1
- 수록면
- 1,047 - 1,055 (9page)
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초록· 키워드
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For the search of a potent first-in-class compound to inactivate macrophages responsible for inflammatory responses, in the present study, we investigated the anti-inflammatory effects of YH-1118, a novel synthetic compound, in a lipopolysaccharide (LPS)-stimulated mouse macrophage cell line, Raw 264.7. YH-1118 inhibited LPS-induced nitric oxide (NO) production and inducible NO synthase (iNOS) expression at both the protein and mRNA levels. The suppression of LPS-induced iNOS expression by YH-1118 was mediated via nuclear factor kappa B (NF-κB), but not activator protein-1 (AP-1) transcription factor. This was supported by the finding that YH-1118 attenuated the phosphorylation of inhibitor of κBα (IκBα) and nuclear translocation and DNA binding activity of NF-κB. Through the mechanisms that YH- 1118 inhibited the activation of IκB kinases (IKKs), upstream activators of NF-κB, or p38 MAPK, YH-1118 significantly suppressed LPS-induced production of pro-inflammatory cytokines, tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6 (p < 0.05). In conclusion, our results suggest that YH-1118 inhibits LPS-induced inflammatory responses by blocking IKK and NF-κB activation in macrophages, and may be a therapeutic candidate for the treatment of various inflammatory diseases.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bertolini A / 2001 / Dual acting antiinflammatory drugs: a reappraisal / Pharmacol. Res 44 : 437 ~ 450
Broad A / 2006 / like receptor (TLR)response tolerance: a key physiological “damage limitation”effect and an important potential opportunity for therapy / Curr. Med. Chem 1
Brockman JA / 1995 / Coupling of a signal response domain in I kappa B alpha to multiple pathways for NFkappa B activation / Mol. Cell. Biol 15 : 2809 ~ 2818
Carter AB / 1999 / The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP) / J. Biol. Chem 274 :
Chan ED / 2001 / IFN-gamma + LPS induction of iNOS is modulated b y ERK, JNK/SAPK, and p 38(mapk) in a mouse macrophage cell line / Am. J. Physiol. Cell Physiol 280 : C441 ~
Broad A / 2006 / like receptor (TLR)response tolerance: a key physiological “damage limitation”effect and an important potential opportunity for therapy / Curr. Med. Chem 1
Brockman JA / 1995 / Coupling of a signal response domain in I kappa B alpha to multiple pathways for NFkappa B activation / Mol. Cell. Biol 15 : 2809 ~ 2818
Carter AB / 1999 / The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP) / J. Biol. Chem 274 :
Chan ED / 2001 / IFN-gamma + LPS induction of iNOS is modulated b y ERK, JNK/SAPK, and p 38(mapk) in a mouse macrophage cell line / Am. J. Physiol. Cell Physiol 280 : C441 ~
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