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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제3호
- 발행연도
- 2005.1
- 수록면
- 551 - 559 (9page)
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초록· 키워드
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The recent rapid increase in genomic data relatedto many microorganisms and the development of computationaltools to acurately analyze large amounts of data have enabledus to design several kinds of simulation approaches for thecomplex behaviors of cels. Among these aproaches, dFBAequations, and regulatory events, has correctly predicted cellularbehaviors under given environmental conditions. However,until now, dFBA has centered on substrate concentration, celgrowth, and gene on/off, but a detailed hierarchical structureof a regulatory network has not been taken into acount. Theuse of Boolean rules for regulatory events in dFBA haslimited the representation of interactions between specificregulatory proteins and genes and the whole transcriptionalregulation mechanism with environmental change. In this paper,hierarchical structure for a regulatory network with definedfundamental symbols, and introduced a weight between symbolsin order to solve the above problems. Finally, the total controlmechanism of regulatory elements (operons, genes, effectors,etc.) with time was simulated through the linkage of dFBAwith regulatory network modeling. The lac operon, trpoperon, and tna operon in the central metabolic network of E.coli were chosen as the basic models for control patterns. Thesuggested modeling method in this study can be adopted as abasic framework to describe other transcriptional regulations,and provide biologists and engineers with useful informationon transcriptional regulation mechanisms under extracellularenvironmental change.
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참고문헌 (26)
참고문헌 신청
Adhya, S / 1996 / The lac and gal operons today (in Regulation of Gene Expression in Escherichia coli) / Chapman & Hall, New York, U.S.A. : 181 ~ 200
Cotter, P. A / 1992 / Contribution of the Fnr and ArcA gene products in coordinate regulation of cytochrome o and d oxidase (cyoABCDE and cydAB) genes in Escherichia coli / F
Covert, M. W / 2001 / Regulation of gene expression in flux balance models of metabolism / J. Theor. Biol. 213 : 73 ~ 88
Covert, M. W / 2002 / Transcriptional regulation in constraints-based metabolic models of Escherichia coli / J. Biol. Chem. 277
Covert, M. W / 2004 / Integrating high-throughput and computational data elucidates bacterial networks / Nature 429 : 92 ~ 96
Cotter, P. A / 1992 / Contribution of the Fnr and ArcA gene products in coordinate regulation of cytochrome o and d oxidase (cyoABCDE and cydAB) genes in Escherichia coli / F
Covert, M. W / 2001 / Regulation of gene expression in flux balance models of metabolism / J. Theor. Biol. 213 : 73 ~ 88
Covert, M. W / 2002 / Transcriptional regulation in constraints-based metabolic models of Escherichia coli / J. Biol. Chem. 277
Covert, M. W / 2004 / Integrating high-throughput and computational data elucidates bacterial networks / Nature 429 : 92 ~ 96
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