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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제3호
- 발행연도
- 2008.1
- 수록면
- 512 - 519 (8page)
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초록· 키워드
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Three different polysaccharide-peptide complexes (PPC,
named as Fr-I, Fr-II, and Fr-III) were produced by
submerged mycelial culture of an entomopathogenic
fungus Cordyceps sphecocephala, and their anticancer
activities were investigated in human hepatocarcinoma
(HepG2) and neuroblastoma (SK-N-SH) cells. The highest
inhibitory effects of PPC on both HepG2 and SK-N-SH
cells were achieved with Fr-I, whereas Fr-III with low
molecular mass showed lower inhibition effects. Interestingly,
the inhibitory effects of the three fractions were increased
after protease digestion, suggesting that the inhibitory
effects resulted mainly from the carbohydrate moiety, at
least in the case of Fr-II and Fr-III, of PPC. The results of
DNA fragmentation in PPC-induced apoptotic cells were
confirmed by both DNA ladder assay and comet assay.
Our investigation also showed that PPC-induced apoptosis
of both cancer cells was associated with intracellular events
including DNA fragmentation, activation of caspase-3,
and modulation of Bcl-2 and Bax. We conclude that PPC
has potential as a novel therapeutic agent for the treatment
of both HepG2 and SK-N-SH cancer cells without any
cytotoxicity against normal cells.
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참고문헌 (23)
참고문헌 신청
Bradford, M. M / 1976 / A rapid and sensitive method for the quantization of microgram quantities of protein utilizing the principle of protein-dye binding. Anal / Biochem 72
Budihardjo, I. / 1999 / Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev / Biol 15 : 269 ~ 290
CHOI, DUBOK / 2007 / Exopolysaccharide Production and Mycelial Growth in an Air-Lift BioreactorUsing Fomitopsis pinicola / Journal of Microbiology and Biotechnology 17 (8) :
Chen, Y. J. / 1997 / Effects of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells / Life Sci 60 : 2349 ~ 2359
Compton, M. M. / 1992 / A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome. Cancer Met / Rev 11 : 105 ~ 119
Budihardjo, I. / 1999 / Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev / Biol 15 : 269 ~ 290
CHOI, DUBOK / 2007 / Exopolysaccharide Production and Mycelial Growth in an Air-Lift BioreactorUsing Fomitopsis pinicola / Journal of Microbiology and Biotechnology 17 (8) :
Chen, Y. J. / 1997 / Effects of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells / Life Sci 60 : 2349 ~ 2359
Compton, M. M. / 1992 / A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome. Cancer Met / Rev 11 : 105 ~ 119
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