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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,401 - 1,408 (8page)
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초록· 키워드
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Petiveria alliacea L. (Phytolacaceae) is a medicinal plant with a broad range of traditional therapeutic properties, including the treatment of dysentery and intestinal infections caused by protozoan parasites. However, its effects against Entamoeba histolytica have not been reported yet. We investigated the antiamoebic activity present in the leaves of P. alliacea Antiamoebic activity was evaluated in methanolic and aqueous extracts, as well as in the hexanic, methanolic, and EtOAc fractions. The P. alliacea methanolic extract showed a better antiamoebic activity than the aqueous extract with an IC50 = 0.51 mg/ml. Likewise, the hexanic fraction was the most effective fraction, showing a dose-dependent activity against E. histolytica, with an IC50 = 0.68 mg/ml. Hexanic subfraction 12-19 showed the highest antiamoebic activity at 0.8 mg/ml, producing 74.3% growth inhibition without any toxicity in mammal cells. A major component in subfraction 12-19 was identified as isoarborinol, which produced 51.4% E. histolytica growth inhibition at 0.05 mg/ml without affecting mammal cells.
The P. alliacea leaf extract has antiamoebic activity that can be attributed to a major metabolite known as isoarborinol.
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참고문헌 (26)
참고문헌 신청
/ / Biblioteca Digital de la Medicina Tradicional Mexicana
AlMusayeib NM / 2013 / In vitro antiprotozoal activity of triterpenoid constituents of Kleinia odora growing in Saudi Arabia / Molecules 18 : 9207 ~ 9218
Berger I / 1998 / Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cru
Bolanos V / 2014 / The flavonoid (?)-epicatechin affects cytoskeleton proteins and functions in Entamoeba histolytica / J. Proteomics 111 : 74 ~ 85
Caceres A / 1998 / Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plan
AlMusayeib NM / 2013 / In vitro antiprotozoal activity of triterpenoid constituents of Kleinia odora growing in Saudi Arabia / Molecules 18 : 9207 ~ 9218
Berger I / 1998 / Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cru
Bolanos V / 2014 / The flavonoid (?)-epicatechin affects cytoskeleton proteins and functions in Entamoeba histolytica / J. Proteomics 111 : 74 ~ 85
Caceres A / 1998 / Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plan
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