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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제3호
- 발행연도
- 2015.1
- 수록면
- 328 - 333 (6page)
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초록· 키워드
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A Myagropsis myagroides (Mm) methanol extract showed α-amylase inhibitory activity of 13% at a concentration of 5 mg/ml. Results showed that the hexane fraction from the Mm methanol extract exhibited α-amylase inhibitory activity with an IC50 value of 4.24 mg/ml. The hexane fraction was separated using silica-gel column chromatography, and six subfractions were obtained. The fraction eluted with CHCl3:MeOH = 50:1 showed the highest α-amylase inhibitory activity with an IC50 value of 0.72 mg/ml. This fraction was purified using Sephadex LH-20 column chromatography and an octadecyl silica (ODS) Sepak cartridge, obtaining seven subfractions. Fraction (Fr.) 4 also showed a strong α-amylase inhibitory activity with an IC50 value of 0.75 mg/ml. Fr. 4 was purified by Sephadex LH-20 column chromatography and ODS Sepak cartridge, obtaining six subfractions. Fr. 4-2 was identified as sargachromanol I with an IC50 value of 0.40 mg/ml, and the inhibition pattern analyzed from Lineweaver-Burk plots revealed it to be an uncompetitive inhibitor. These results suggest that Mm has potential as a natural antidiabetes agent.
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참고문헌 (27)
참고문헌 신청
Ali H / 2006 / α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus / J. Ethnopharmacol 107 : 449 ~
Athukorala Y / 2007 / Anticoagulant activity of marine green and brown algae collected from Jeju island in Korea / Bioresour. Technol 98 : 1711 ~ 1716
Chrzaszcz T / 1933 / “Sisto-amylase”, a natural inhibitor of amylase / Biochem. Z 260 : 354 ~ 368
Chung SC / 2011 / Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase / Bioorg. Med. Chem. Lett 21 : 1958 ~ 1961
Dias SC / 2005 / Molecular cloning and expression of an α-amylase inhibitor from rye with potential for controlling insect pests / Protein J 24 : 113 ~ 123
Athukorala Y / 2007 / Anticoagulant activity of marine green and brown algae collected from Jeju island in Korea / Bioresour. Technol 98 : 1711 ~ 1716
Chrzaszcz T / 1933 / “Sisto-amylase”, a natural inhibitor of amylase / Biochem. Z 260 : 354 ~ 368
Chung SC / 2011 / Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase / Bioorg. Med. Chem. Lett 21 : 1958 ~ 1961
Dias SC / 2005 / Molecular cloning and expression of an α-amylase inhibitor from rye with potential for controlling insect pests / Protein J 24 : 113 ~ 123
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