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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제5호
- 발행연도
- 2018.1
- 수록면
- 679 - 687 (9page)
이용수
초록· 키워드
오류제보하기
Korean red pine (Pinus densiflora) is one of the major Pinus species in Korea. Red pine bark is removed prior to the chipping process in the wood industry and discarded as waste. However, red pine bark contains a considerable amount of naturally occurring phenolics, including flavonoids, and therefore may have a variety of biological effects. In this study, we investigated if Korean red pine bark extract (KRPBE) could protect neuronal PC-12 cells from oxidative stress and inhibit cholinesterase activity. Analysis of reversed-phase high-performance liquid chromatography results revealed four phenolics in KRPBE: vanillin, protocatechuic acid, catechin, and taxifolin. The total phenolic and flavonoid contents of KRPBE were 397.9 mg gallic acid equivalents/g dry weight (DW) and 248.7 mg catechin equivalents/g DW, respectively. The antioxidant capacities of KRPBE measured using ABTS, DPPH, and ORAC assays were 697.3, 521.8, and 2,627.7 mg vitamin C equivalents/g DW, respectively. KRPBE and its identified phenolics protected against H2O2-induced oxidative cell death in a dosedependent manner. Acetylcholinesterase and butyrylcholinesterase, which degrade the neurotransmitter acetylcholine to terminate neurotransmission in synaptic clefts, were inhibited by treatment with KRPBE and its identified phenolics. Taken together, these results suggest that KRPBE and its constituent antioxidative phenolics are potent neuroprotective agents that can maintain cell viability under oxidative stress and inhibit cholinesterase activity.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Jekel K / 2015 / Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review / Alzheimers Res. Ther. 7:17
Mendez-Armenta M / 2014 / Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy / Oxid. Med. Cell. Longev. 2014:293689
Darvesh S / 2016 / Butyrylcholinesterase as a diagnostic and therapeutic target for Alzheime's disease / Curr. Alzheimer Res. 13:1173~1177
Mehta M / 2012 / New acetylcholinesterase inhibitors for Alzheimer's disease / Int. J. Alzheimers Dis. 2012:728983
Ku CS / 2007 / Exploitation of polyphenol- rich pine barks for potent antioxidant activity / J. Wood Sci. 53:524~528
Mendez-Armenta M / 2014 / Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy / Oxid. Med. Cell. Longev. 2014:293689
Darvesh S / 2016 / Butyrylcholinesterase as a diagnostic and therapeutic target for Alzheime's disease / Curr. Alzheimer Res. 13:1173~1177
Mehta M / 2012 / New acetylcholinesterase inhibitors for Alzheimer's disease / Int. J. Alzheimers Dis. 2012:728983
Ku CS / 2007 / Exploitation of polyphenol- rich pine barks for potent antioxidant activity / J. Wood Sci. 53:524~528
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