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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 11 - 18 (8page)
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Human bone marrow mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tenden, muscle, and marrow stroma.
Cells that have the characteristics of human mesenchymal stem cells could be isolated from marrow aspirates of human and animals. This study was designed to identify and characterize genes specifically expressed by osteogenic supplements -treated cells by suppression subtractive hybridization(SSH) method.
The results were as follows:
1. 2 genes were upregulated genes in osteogenic diffeentiation of hMSCs, which is further proved by Northern blot analysis.
2. IGFBP-2 has been identified playing an important role in bone formation.
3. HF1 was also upregulated during osteogenic differentiation, but its role in bone formation is not clear yet
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Binkert C / 1989 / Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2) / EMBO J 8 (9) : 2497 ~ 2502
Bruder SP / 1994 / Mesenchymal Stem Cells in Bone Development, Bone Repair and Skeletal Regeneration Therapy / J Cell Biochem 56 : 283 ~ 294
Canalis E / 1997 / Insulin-like Growth Factors and Osteoporosis / Bone 21 : 215 ~ 216
Cheng SL / 1994 / Differentiation of Human Bone Marrow Osteogenic Stromal Cells in vitro: Induction of the Osteoblast phenotype by dexamethasone / Endocrinology 134 : 277 ~ 2
Cheng SL / 1998 / Regulation of Insulin-like Growth Factors I and II and their Binding Proetins in Human Bone Marrow Stromal Cells by Dexamethasone / J Cell Biochem 71 : 449
Bruder SP / 1994 / Mesenchymal Stem Cells in Bone Development, Bone Repair and Skeletal Regeneration Therapy / J Cell Biochem 56 : 283 ~ 294
Canalis E / 1997 / Insulin-like Growth Factors and Osteoporosis / Bone 21 : 215 ~ 216
Cheng SL / 1994 / Differentiation of Human Bone Marrow Osteogenic Stromal Cells in vitro: Induction of the Osteoblast phenotype by dexamethasone / Endocrinology 134 : 277 ~ 2
Cheng SL / 1998 / Regulation of Insulin-like Growth Factors I and II and their Binding Proetins in Human Bone Marrow Stromal Cells by Dexamethasone / J Cell Biochem 71 : 449
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