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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한구강악안면외과학회 대한구강악안면외과학회지 대한구강악안면외과학회지 제34권 제1호
발행연도
2008.1
수록면
36 - 48 (13page)

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초록· 키워드

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To repair bone defects in the oral and maxillofacial field, bone grafts including autografts, allografts, and artificial bone are used in clinical dentistry despite several disadvantages. The purpose of this study was to evaluate new bone formation and healing in rat calvarial bone defects using hydroxyapatite (HA, Ca10[PO4]6[OH]2, Bongros􀋓, Bio@ Co., KOREA) and tricalcium phosphate (β-TCP, Ca3[PO4]2, Sigma-Aldrich Co., USA) mixed at various ratios. Additionally, this study evaluated the effects of type I collagen (Rat tail, BD Biosciences Co., Sweden) as a basement membrane organic matrix. A total of twenty, 8-week-old, male Sprague-Dawley rats, weighing 250-300g, were divided equally into a control group (n=2) and nine experimental groups (n=2, each). Bilateral, standardized transosseous circular calvarial defects, 5.0 mm in diameter, were created. In each experimental group, the defect was filled with HA and TCP at a ratio of 100:0, 80:20, 70:30, 60:40, 50:50, 40:60, 30:70, 20:80, and 0:100 with or without type I collagen. Rats were sacrificed 4 and 8 weeks post-operation for radiographic (standardized plain film, Kodak Co., USA), histomorphologic (H&E [Hematoxylin and Eosin], MT [Masson Trichrome]), immunohistochemical staining (for BMP-2, -4, VEGF, and vWF), and elementary analysis (Atomic absorption spectrophotometer, Perkin Elmer AAnalyst 100􀋓). As the HA proportion increased, denser radiopacity was seen in most groups at 4 and 8 weeks. In general radiopacity in type I collagen groups was greater than the non-collagen groups, especially in the 100% HA group at 8 weeks. No new bone formation was seen in calvarial defects in any group at 4 weeks. Bridging bone formation from the defect margin was marked at 8 weeks in most type I collagen groups. Although immunohistochemical findings with BMP-2, -4, and VEGF were not significantly different, marked vWF immunoreactivity was present. vWF staining was especially strong in endothelial cells in newly formed bone margins in the 100:0, 80:20, and 70:30 ratio type I collagen groups at 8 weeks. The calcium compositions from the elementary analysis were not statistically significant. Many types of artificial bone have been used as bone graft materials, but most of them can only be applied as an inorganic material. This study confirmed improved bony regeneration by adding organic type I collagen to inorganic HA and TCP mixtures. Therefore, these new artificial bone graft materials, which are under strict storage and distribution systems, will be suggested to be available to clinical dentistry demands.
#Bone graft #BMP #Hydroxyapatite #Ca10[PO4]6[OH]2) #Tricalcium phosphate #Ca3[PO4]2) #Type I collagen #VEGF #vWF

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참고문헌 (26)

참고문헌 신청
Andrade JCT / 2002 / Behavior of dense and porous hydroxyapatite implants and tissue response in rat femoral defects / J Biomed Master Res 62 : 30 ~ 36 google schola Barrack RL / 2003 / Induction of bone ingrowth form acetabular defects to a porous surface with OP-1○R / Clin Orthop 417 : 41 ~ 49 google schola Breitbart AS / 1995 / Tricalcium phosphate and osteogenin: a bioactive on lay bone graft substitute / Plast Reconstr Surg 96 : 699 ~ 708 google schola Broecke DGA / 1998 / Neurotmesis of the lateral femoral cutaneous nerve when coring for iliac crest bone grafts / Plast Reconstr Surg 102 : 1163 ~ 1166 google schola Bruchardt H / 1978 / Freeze-dried allogenic segmental cortical-bone grafts in dogs / J Bone Joint Surg 60 : 1082 ~ 1090 google schola

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