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대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제38권 제2호
발행연도
2008.1
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163 - 170 (8page)

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Purpose: Biphasic calcium phosphates have been of great interest recently. Mixing adequate ratios of hydroxyapatite(HA) and beta-tricalcium phosphate(β-TCP) allowed to control the resorption rate without distorting its osteoconductive property. This study evaluated the bone formation effect of newly developed biphasic calcium phosphate(BCP) in calvarial defect of rabbits. Materials and Methods: 6 male New Zealand rabbits were used. Four defects with 8mm in diameter were created on each animal. BCP with HA/β-TCP ratio of 7:3 and particle size of 0.5~1.0mm was used as the test group and bovine bone with 0.25~1.0mm particle size, as the control group. Both test and control group materials were randomly implanted in the calvarial defects and were covered witha polymer membrane. The animals were sacrificed after 12, 24, and 48 weeks of implantation under general euthanasia. Resin blocks were obtained and were stained by masson's trichrome for histological observation. Results: Overall results were uneventful without any defect exposure or inflammation. The amount of new bone formation and bone maturity increased with increase in healing period at both groups. New bone in test group was mostly formed along the material particle surrounded by osteoblasts, and observation of osteoblastic stream was also present. Bone maturity increased as it was closer to thedefect margins. Under the same healing period, the test group showed more bone formation than the control group with more stable bovine bone particles remaining even after 48 weeks, whereas considerable resorption took place in BCP. Almost total defect closure was observed in test group with new bone formation in the central part of the defect. However, limited new bone formation was observed in the control group. Conclusion: Within the limits of the study, the present study reveals the newly developed BCP to be a good osteoconductive material. However, further studies are needed to be conducted in a different study model with a larger sample size. (J Korean Acad Periodontol 2008;38:163-170)
#Hydroxyapatite #beta-tricalcium phosphate #bone graft #calvarial defect.

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참고문헌 (23)

참고문헌 신청
Daculsi G / 1989 / Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization / J Biomed Mater Res 23 : 883 ~ 894 google schola Daculsi G / 1990 / Formation of Carbonate-apatite crystals after implantation of calcium phosphate ceramics / Calcification Tissue International 46 : 20 ~ 27 google schola Daculsi G / 1990 / Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study / J Biomed Mater Res 24 : 379 ~ 396 google schola Fleckenstein KB / 2006 / Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium / J Periodontol 77 : 39 ~ 45 google schola Gao H / 2004 / Effect of composition on the release kinetics of phosphate controlled release glasses in aqueous medium / J Control Release 96 : 21 ~ 28 google schola

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