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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: It has been reported that the microporous structure of calcium phosphate (CaP) ceramics is important to osteoconduction. Bone morphogenetic protein-2 (BMP-2) has been shown to be a promising alternative to bone grafting and a therapeutic agent promoting bone regeneration when delivered locally. The aim of this study was to evaluate the effects of micro-porosity within beta-tricalcium phosphate (β-TCP) cylinders and local BMP-2 administration on β-TCP resorption and new bone formation. Methods: Bilateral cylindrical bone defects were created in rabbit distal femora, and the defects were filled with β-TCP. Rabbits were divided into 3 groups; defects were filled with a β-TCP cylinder with a total of approximately 60% porosity (Group A: 13.4% micro- and 46.9% macropore, Group B: 38.5% micro- and 20.3% macropore, Group C: the same micro- and macro-porosity as in group B supplemented with BMP-2). Rabbits were sacrificed 4, 8, 12, and 24 weeks postoperatively. Results: The number of TRAP-positive cells and new bone formation in group B were significantly greater than those in group A at every period. The amount of residual β-TCP in group C was less than that in group B at all time periods, resulting in significantly more new bone formation in group C at 8 and 12 weeks. The number of TRAPpositive cells in group C was maximum at 4 weeks. Conclusions: These results suggest that the amount of submicron microporous structure and local BMP-2 administration accelerated both osteoclastic resorption of β-TCP and new bone formation, probably through a coupling-like phenomenon between resorption and new bone formation.
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참고문헌 (50)
참고문헌 신청
Ohura K / 1996 / Resorption of and bone formation from, new beta-tricalcium phosphate-monocalcium phosphate ceramics / J Biomed Mater Res 30:193~200
Dong J / 2002 / Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteogenitor cells / Biomaterials 23:4493~4502
Ogose A / 2002 / Histological examination of beta-tricalcium phosphate graft in human femur / J Biomed Mater Res 63:601~604
Chazono M / 2004 / Bone formation and bioresorption after implantation of injectable beta-tricalcium phosphate granules-hyaluronate complex in rabbit bone defects / J Biomed Mater Res A 70:542~549
Komaki H / 2006 / Repair of segmental bone defects in rabbit tibiae using a complex of beta-tricalcium phosphate, type I collagen, and fibroblast growth factor-2 / Biomaterials 27:5118~5126
Dong J / 2002 / Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteogenitor cells / Biomaterials 23:4493~4502
Ogose A / 2002 / Histological examination of beta-tricalcium phosphate graft in human femur / J Biomed Mater Res 63:601~604
Chazono M / 2004 / Bone formation and bioresorption after implantation of injectable beta-tricalcium phosphate granules-hyaluronate complex in rabbit bone defects / J Biomed Mater Res A 70:542~549
Komaki H / 2006 / Repair of segmental bone defects in rabbit tibiae using a complex of beta-tricalcium phosphate, type I collagen, and fibroblast growth factor-2 / Biomaterials 27:5118~5126
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